Antimicrobial sensitisers: Gatekeepers to avoid the development of multidrug-resistant bacteria

被引：2
作者：
Wang, Hanfei [1 ,2 ]
Yang, Yingying [1 ,2 ]
Wang, Simeng [1 ,2 ]
Badawy, Sara [3 ,4 ]
Ares, Irma [5 ,6 ]
Martinez, Marta [5 ,6 ]
Lopez-Torres, Bernardo [5 ,6 ]
Martinez-Larranaga, Maria-Rosa [5 ,6 ]
Wang, Xu [1 ,2 ,3 ]
Anadon, Arturo [5 ,6 ]
Martinez, Maria-Aranzazu [5 ,6 ]
机构：
[1] Huazhong Agr Univ, Natl Reference Lab Vet Drug Residues HZAU, Wuhan 430070, Hubei, Peoples R China
[2] Huazhong Agr Univ, MAO Key Lab Detect Vet Drug Residues, Wuhan 430070, Hubei, Peoples R China
[3] Huazhong Agr Univ, MAO Lab Risk Assessment Qual & Safety Livestock &, Wuhan 430070, Hubei, Peoples R China
[4] Benha Univ, Fac Vet Med, Pathol Dept Anim Med, Banha, Egypt
[5] Univ Complutense Madrid UCM, Fac Vet Med, Dept Pharmacol & Toxicol, Madrid 28040, Spain
[6] Res Inst Hosp 12 De Octubre I 12, Madrid 28040, Spain
来源：
JOURNAL OF CONTROLLED RELEASE | 2024年 / 369卷
基金：
中国国家自然科学基金;
关键词：
Multidrug-resistant bacteria; Antibiotic adjuvant; Antimicrobial sensitizer; Indirect antibacterial; GRAM-NEGATIVE BACTERIA; 3 POSITIVE CHARGES; PSEUDOMONAS-AERUGINOSA; ANTIBIOTIC-RESISTANCE; CLAVULANIC ACID; BETA-LACTAM; IN-VITRO; PEPTIDES; 4-HYDROXYBENZALDEHYDE; SUSCEPTIBILITY;
D O I：
10.1016/j.jconrel.2024.03.031
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The resistance of multidrug-resistant bacteria to existing antibiotics forces the continued development of new antibiotics and antibacterial agents, but the high costs and long timeframe involved in the development of new agents renders the hope that existing antibiotics may again play a part. The "antibiotic adjuvant" is an indirect antibacterial strategy, but its vague concept has, in the past, limited the development speed of related drugs. In this review article, we put forward an accurate concept of a "non-self-antimicrobial sensitisers (NSAS)", to distinguish it from an "antibiotic adjuvant", and then discuss several scientific methods to restore bacterial sensitivity to antibiotics, and the sources and action mechanism of existing NSAS, in order to guide the development and further research of NSAS.
引用
收藏
页码：25 / 38
页数：14
相关论文
共 124 条
  • [1] Design of riboregulators for control of cyanobacterial (Synechocystis) protein expression
    Abe, Koichi
    Sakai, Yuta
    Nakashima, Saki
    Araki, Masataka
    Yoshida, Wataru
    Sode, Koji
    Ikebukuro, Kazunori
    [J]. BIOTECHNOLOGY LETTERS, 2014, 36 (02) : 287 - 294
  • [2] Current situation of carbapenem-resistant Enterobacteriaceae and Acinetobacter in Japan and Southeast Asia
    Akeda, Yukihiro
    [J]. MICROBIOLOGY AND IMMUNOLOGY, 2021, 65 (06) : 229 - 237
  • [3] Cascade Ligand- and Structure-Based Virtual Screening to Identify New Trypanocidal Compounds Inhibiting Putrescine Uptake
    Alberca, Lucas N.
    Sbaraglini, Maria L.
    Morales, Juan F.
    Dietrich, Roque
    Ruiz, Maria D.
    Pino Martinez, Agustina M.
    Miranda, Cristian G.
    Fraccaroli, Laura
    Alba Soto, Catalina D.
    Carrillo, Carolina
    Palestro, Pablo H.
    Talevi, Alan
    [J]. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2018, 8
  • [4] Challenges and opportunities in the discovery, development, and commercialization of pathogen-targeted antibiotics
    Altarac, David
    Gutch, Michael
    Mueller, John
    Ronsheim, Matthew
    Tommasi, Ruben
    Perros, Manos
    [J]. DRUG DISCOVERY TODAY, 2021, 26 (09) : 2084 - 2089
  • [5] Using CRISPR/Cas9 to model human liver disease
    Alves-Bezerra, Michele
    Furey, Nika
    Johnson, Collin G.
    Bissig, Karl-Dimiter
    [J]. JHEP REPORTS, 2019, 1 (05) : 392 - 402
  • [6] Mechanisms and consequences of bacterial resistance to antimicrobial peptides
    Andersson, D. I.
    Hughes, D.
    Kubicek-Sutherland, J. Z.
    [J]. DRUG RESISTANCE UPDATES, 2016, 26 : 43 - 57
  • [7] Strategies to Overcome Antimicrobial Resistance (AMR) Making Use of Non-Essential Target Inhibitors: A Review
    Annunziato, Giannamaria
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (23)
  • [8] Staphylococcus aureus functional amyloids catalyze degradation of β-lactam antibiotics
    Arad, Elad
    Pedersen, Kasper B.
    Malka, Orit
    Mambram Kunnath, Sisira
    Golan, Nimrod
    Aibinder, Polina
    Schiott, Birgit
    Rapaport, Hanna
    Landau, Meytal
    Jelinek, Raz
    [J]. NATURE COMMUNICATIONS, 2023, 14 (01)
  • [9] Synergistic interactions of phytochemicals with antimicrobial agents: Potential strategy to counteract drug resistance
    Ayaz, Muhammad
    Ullah, Farhat
    Sadiq, Abdul
    Ullah, Farman
    Ovais, Muhammad
    Ahmed, Jawad
    Devkota, Hari Prasad
    [J]. CHEMICO-BIOLOGICAL INTERACTIONS, 2019, 308 : 294 - 303
  • [10] Genetic Dissection of Antibiotic Adjuvant Activity
    Bailey, J.
    Gallagher, L.
    Barker, W. T.
    Hubble, V. B.
    Gasper, J.
    Melander, C.
    Manoil, C.
    [J]. MBIO, 2022, 13 (01):
12345678910