Functional Genomics in Psoriasis

被引：1
作者：
Rossi, Stefano [1 ]
Richards, Ellie Louise [1 ]
Orozco, Gisela [1 ]
Eyre, Stephen [1 ]
机构：
[1] Univ Manchester, Fac Biol Med & Hlth, Ctr Genet & Genom Versus Arthrit, Div Musculoskeletal & Dermatol Sci, Manchester M13 9PL, England
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 13期
关键词：
psoriasis; functional genomics; GWAS; inflammation; precision medicine; SUSCEPTIBILITY LOCI; WIDE ASSOCIATION; DRUG DISCOVERY; HLA-C; DISEASE; RISK; GENETICS; POLYMORPHISM; IDENTIFICATION; HERITABILITY;
D O I：
10.3390/ijms25137349
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Psoriasis is an autoimmune cutaneous condition that significantly impacts quality of life and represents a burden on society due to its prevalence. Genome-wide association studies (GWASs) have pinpointed several psoriasis-related risk loci, underlining the disease's complexity. Functional genomics is paramount to unveiling the role of such loci in psoriasis and disentangling its complex nature. In this review, we aim to elucidate the main findings in this field and integrate our discussion with gold-standard techniques in molecular biology-i.e., Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-and high-throughput technologies. These tools are vital to understanding how disease risk loci affect gene expression in psoriasis, which is crucial in identifying new targets for personalized treatments in advanced precision medicine.
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页数：16
相关论文
共 126 条
[1]  
Adler BL, 2017, JAMA DERMATOL, V153, P810, DOI [10.1001/jamadermatol.2017.1297, 10.1001/jamadermatol.2017.2103]
[2]   Comparison of Capture Hi-C Analytical Pipelines [J].
Aljogol, Dina ;
Thompson, I. Richard ;
Osborne, Cameron S. ;
Mifsud, Borbala .
FRONTIERS IN GENETICS, 2022, 13
[3]  
Allen M, 2003, AM J HUM GENET, V73, P430
[4]   The major psoriasis susceptibility locus PSORS1 is not a risk factor for late-onset psoriasis [J].
Allen, MH ;
Ameen, H ;
Veal, C ;
Evans, J ;
Ramrakha-Jones, VS ;
Marsland, AM ;
Burden, AD ;
Griffiths, CEM ;
Trembath, RC ;
Barker, JNWN .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2005, 124 (01) :103-106
[5]   ERAP1 Controls the Autoimmune Response against Melanocytes in Psoriasis by Generating the Melanocyte Autoantigen and Regulating Its Amount for HLA-C*06:02 Presentation [J].
Arakawa, Akiko ;
Reeves, Emma ;
Vollmer, Sigrid ;
Arakawa, Yukiyasu ;
He, Mengwen ;
Galinski, Adrian ;
Stoehr, Julia ;
Dornmair, Klaus ;
James, Edward ;
Prinz, Joerg C. .
JOURNAL OF IMMUNOLOGY, 2021, 207 (09) :2235-2244
[6]   CAR T therapy beyond cancer: the evolution of a living drug [J].
Baker, Daniel J. ;
Arany, Zoltan ;
Baur, Joseph A. ;
Epstein, Jonathan A. ;
June, Carl H. .
NATURE, 2023, 619 (7971) :707-715
[7]   Hi-C: A comprehensive technique to capture the conformation of genomes [J].
Belton, Jon-Matthew ;
McCord, Rachel Patton ;
Gibcus, Johan Harmen ;
Naumova, Natalia ;
Zhan, Ye ;
Dekker, Job .
METHODS, 2012, 58 (03) :268-276
[8]   The NIH Roadmap Epigenomics Mapping Consortium [J].
Bernstein, Bradley E. ;
Stamatoyannopoulos, John A. ;
Costello, Joseph F. ;
Ren, Bing ;
Milosavljevic, Aleksandar ;
Meissner, Alexander ;
Kellis, Manolis ;
Marra, Marco A. ;
Beaudet, Arthur L. ;
Ecker, Joseph R. ;
Farnham, Peggy J. ;
Hirst, Martin ;
Lander, Eric S. ;
Mikkelsen, Tarjei S. ;
Thomson, James A. .
NATURE BIOTECHNOLOGY, 2010, 28 (10) :1045-1048
[9]   Long-term expansion and differentiation of adult murine epidermal stem cells in 3D organoid cultures [J].
Boonekamp, Kim E. ;
Kretzschmar, Kai ;
Wiener, Dominique J. ;
Asra, Priyanca ;
Derakhshan, Sepideh ;
Puschhof, Jens ;
Lopez-Iglesias, Carmen ;
Peters, Peter J. ;
Basak, Onur ;
Clevers, Hans .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (29) :14630-14638
[10]   Role of the IL-23/IL-17 Axis in Psoriasis and Psoriatic Arthritis: The Clinical Importance of Its Divergence in Skin and Joints [J].
Boutet, Marie-Astrid ;
Nerviani, Alessandra ;
Afflitto, Gabriele Gallo ;
Pitzalis, Costantino .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 19 (02)
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