Serum Uric Acid, Hypertriglyceridemia, and Carotid Plaques: A Sub-Analysis of the URic Acid Right for Heart Health (URRAH) Study

被引：2

作者：

Agabiti Rosei, Claudia ^{[1
,2
]}

Paini, Anna ^{[1
,2
]}

Buso, Giacomo ^{[1
,2
]}

Maloberti, Alessandro ^{[3
,4
]}

Giannattasio, Cristina ^{[3
,4
]}

Salvetti, Massimo ^{[1
,2
]}

Casiglia, Edoardo ^{[5
]}

Tikhonoff, Valerie ^{[6
]}

Angeli, Fabio ^{[7
,8
]}

Barbagallo, Carlo Maria ^{[9
]}

Bombelli, Michele ^{[10
]}

Cappelli, Federica ^{[11
]}

Cianci, Rosario ^{[12
]}

Ciccarelli, Michele ^{[13
]}

Cicero, Arrigo Francesco Giuseppe ^{[14
,15
]}

Cirillo, Massimo ^{[16
]}

Cirillo, Pietro ^{[17
]}

Dell'Oro, Raffaella ^{[10
]}

D'Elia, Lanfranco ^{[18
]}

Desideri, Giovambattista ^{[19
]}

Ferri, Claudio ^{[20
]}

Galletti, Ferruccio ^{[18
]}

Gesualdo, Loreto ^{[17
]}

Grassi, Guido ^{[10
]}

Iaccarino, Guido ^{[13
]}

Lippa, Luciano ^{[21
]}

Mallamaci, Francesca ^{[22
]}

Masi, Stefano ^{[11
]}

Masulli, Maria ^{[18
]}

Mazza, Alberto ^{[23
]}

Mengozzi, Alessandro ^{[11
,24
,25
]}

Nazzaro, Pietro ^{[26
]}

Palatini, Paolo ^{[5
]}

Parati, Gianfranco ^{[27
,28
]}

Pontremoli, Roberto ^{[29
]}

Quarti-Trevano, Fosca ^{[10
]}

Rattazzi, Marcello ^{[30
]}

Reboldi, Gianpaolo ^{[31
]}

Rivasi, Giulia ^{[32
]}

Russo, Elisa ^{[29
]}

Tocci, Giuliano ^{[33
]}

Ungar, Andrea ^{[32
]}

Verdecchia, Paolo ^{[34
]}

Viazzi, Francesca ^{[29
]}

Volpe, Massimo ^{[33
,35
]}

Virdis, Agostino ^{[11
]}

Muiesan, Maria Lorenza ^{[1
,2
]}

Borghi, Claudio ^{[14
,15
]}

机构：

[1] Univ Brescia, Dept Clin & Expt Sci, Piazzale Spedali Civili 1, I-25123 Brescia, Italy

[2] ASST Spedali Civili Brescia, Piazzale Spedali Civili 1, I-25123 Brescia, Italy

[3] Osped Niguarda Ca Granda, ADe Gasperis Dept, Cardiol 4, I-20162 Milan, Italy

[4] Milano Bicocca Univ, Sch Med & Surg, I-20126 Milan, Milano, Italy

[5] Univ Padua, Dept Med, Studium Patavinum, I-35100 Padua, Italy

[6] Univ Padua, Dept Med, I-35100 Padua, Italy

[7] Univ Insubria, Dept Med & Surg, I-21100 Varese, Italy

[8] IRCCS, Maugeri Care & Res Inst, Ist Ricovero & Cura Carattere Sci Tradate, Dept Med & Cardiopulm Rehabil, I-21100 Varese, Italy

[9] Univ Palermo, Biomed Dept Internal Med & Specialist, I-90100 Palermo, Italy

[10] Univ Milano Bicocca, Dept Med & Surg, Clin Med, I-20900 Monza, Italy

[11] Univ Pisa, Dept Clin & Expt Med, I-56126 Pisa, Italy

[12] Sapienza Univ Rome, Dept Translat & Precis Med, I-00185 Rome, Italy

[13] Federico II Univ Naples, Dept Adv Biomed Sci, I-80133 Naples, Italy

[14] Univ Bologna, Res Ctr, Dept Hypertens & Cardiovasc Dis, Med & Surg Sci Dept,Alma Mater Studiorum, I-40126 Bologna, Italy

[15] IRCCS AOU Bologna, Heart Chest Vasc Dept, I-40126 Bologna, Italy

[16] Federico II Univ Naples, Dept Publ Hlth, I-80133 Naples, Italy

[17] Aldo Moro Univ Bari, Dept Emergency & Organ Transplantat, Nephrol Dialysis & Transplantat Unit, I-70122 Bari, Italy

[18] Federico II Univ Naples, Dept Clin Med & Surg, Physiol Nutr Unit, I-80133 Naples, Italy

[19] Univ Rome, Dept Clin Internal Anesthesiol & Cardiovasc Sci Sa, I-00161 Rome, Italy

[20] Univ Laquila, Dept Life Hlth & Environm Sci, I-67100 Laquila, Italy

[21] Italian Soc Gen Med SIMG, I-67051 Avezzano, Italy

[22] CNR IFC, Reggio Cal Unit, Clin Epidemiol Renal Dis & Hypertens, Reggio Cal Unit, I-89124 Reggio Di Calabria, Italy

[23] AULSS 5 Polesana, Santa Maria Misericordia Gen Hosp, Dept Internal Med, I-45100 Rovigo, Italy

[24] Univ Zurich, Univ Hosp Zurich, Ctr Translat & Expt Cardiol CTEC, Dept Cardiol, CH-8952 Schlieren, Switzerland

[25] Res Univ, St Anna Sch Adv Studies, I-56127 Pisa, Italy

[26] Univ Bari Med Sch, Dept Precis & Regenerat Med & Jon Area DiMePRe J, Neurosci & Sense Organs, I-70122 Bari, Italy

[27] Inst San Luca Hosp, Ist Ricovero & Cura Carattere Sci IRCCS, Ist Auxol Italiano, Dept Cardiol, I-20149 Milan, Italy

[28] Univ Milano Bicocca, Dept Med & Surg, I-20126 Milan, Italy

[29] Univ Genoa, IRCSS Osped Policlin San Martino, Dept Internal Med, I-16132 Genoa, Italy

[30] Univ Padua, Med Interna CaFoncello Univ Hosp 1, Dept Med DIMED, I-31100 Treviso, Italy

[31] Univ Perugia, Dept Med & Surg Sci, I-06100 Perugia, Italy

[32] Univ Florence, Careggi Hosp, Dept Geriatr & Intens Care Med, I-50121 Florence, Italy

[33] Univ Rome Sapienza, Dept Clin & Mol Med, I-00185 Rome, Italy

[34] Hosp S Maria Misericordia, I-06100 Perugia, Italy

[35] IRCCS San Raffaele, Via Pisana, I-00163 Rome, Italy

来源：

METABOLITES | 2024年 / 14卷 / 06期

关键词：

serum uric acid; triglycerides; cardiovascular risk; carotid plaques; HDL cholesterol; LDL cholesterol; INTIMA-MEDIA THICKNESS; CARDIOVASCULAR-DISEASE; SUBCLINICAL ATHEROSCLEROSIS; TRIGLYCERIDE LEVELS; ALL-CAUSE; ASSOCIATION; MORTALITY; GLUCOSE; HYPERURICEMIA; METAANALYSIS;

D O I：

10.3390/metabo14060323

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

High levels of serum uric acid (SUA) and triglycerides (TG) might promote high-cardiovascular-risk phenotypes, including subclinical atherosclerosis. An interaction between plaques xanthine oxidase (XO) expression, SUA, and HDL-C has been recently postulated. Subjects from the URic acid Right for heArt Health (URRAH) study with carotid ultrasound and without previous cardiovascular diseases (CVD) (n = 6209), followed over 20 years, were included in the analysis. Hypertriglyceridemia (hTG) was defined as TG >= 150 mg/dL. Higher levels of SUA (hSUA) were defined as >= 5.6 mg/dL in men and 5.1 mg/dL in women. A carotid plaque was identified in 1742 subjects (28%). SUA and TG predicted carotid plaque (HR 1.09 [1.04-1.27], p < 0.001 and HR 1.25 [1.09-1.45], p < 0.001) in the whole population, independently of age, sex, diabetes, systolic blood pressure, HDL and LDL cholesterol and treatment. Four different groups were identified (normal SUA and TG, hSUA and normal TG, normal SUA and hTG, hSUA and hTG). The prevalence of plaque was progressively greater in subjects with normal SUA and TG (23%), hSUA and normal TG (31%), normal SUA and hTG (34%), and hSUA and hTG (38%) (Chi-square, 0.0001). Logistic regression analysis showed that hSUA and normal TG [HR 1.159 (1.002 to 1.341); p = 0.001], normal SUA and hTG [HR 1.305 (1.057 to 1.611); p = 0.001], and the combination of hUA and hTG [HR 1.539 (1.274 to 1.859); p = 0.001] were associated with a higher risk of plaque. Our findings demonstrate that SUA is independently associated with the presence of carotid plaque and suggest that the combination of hyperuricemia and hypertriglyceridemia is a stronger determinant of carotid plaque than hSUA or hTG taken as single risk factors. The association between SUA and CVD events may be explained in part by a direct association of UA with carotid plaques.

引用

页数：12