A new perspective on hematological malignancies: m6A modification in immune microenvironment

被引:4
作者
Yang, Shiyu [1 ,2 ]
Xu, Liping [1 ,2 ]
Zhuang, Haihui [1 ,2 ]
Li, Fenglin [1 ,2 ]
Lu, Ying [1 ,2 ]
机构
[1] Ningbo Univ, Affiliated Peoples Hosp, Dept Hematol, Ningbo, Peoples R China
[2] Ningbo Univ, Inst Hematol, Ningbo, Peoples R China
关键词
m6A; hematological malignancies; immune microenvironment; immunotherapy; tumor treatment resistance; MESSENGER-RNA; PROMOTES LEUKEMOGENESIS; MYELOID-LEUKEMIA; STEM-CELLS; METHYLATION; CANCER; METHYLTRANSFERASE; PD-1; PROTEIN; N6-METHYLADENOSINE;
D O I
10.3389/fimmu.2024.1374390
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Immunotherapy for hematological malignancies is a rapidly advancing field that has gained momentum in recent years, primarily encompassing chimeric antigen receptor T-cell (CAR-T) therapies, immune checkpoint inhibitors, and other modalities. However, its clinical efficacy remains limited, and drug resistance poses a significant challenge. Therefore, novel immunotherapeutic targets and agents need to be identified. Recently, N6-methyladenosine (m6A), the most prevalent RNA epitope modification, has emerged as a pivotal factor in various malignancies. Reportedly, m6A mutations influence the immunological microenvironment of hematological malignancies, leading to immune evasion and compromising the anti-tumor immune response in hematological malignancies. In this review, we comprehensively summarize the roles of the currently identified m6A modifications in various hematological malignancies, with a particular focus on their impact on the immune microenvironment. Additionally, we provide an overview of the research progress made in developing m6A-targeted drugs for hematological tumor therapy, to offer novel clinical insights.
引用
收藏
页数:13
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