A new perspective on hematological malignancies: m6A modification in immune microenvironment

被引:3
作者
Yang, Shiyu [1 ,2 ]
Xu, Liping [1 ,2 ]
Zhuang, Haihui [1 ,2 ]
Li, Fenglin [1 ,2 ]
Lu, Ying [1 ,2 ]
机构
[1] Ningbo Univ, Affiliated Peoples Hosp, Dept Hematol, Ningbo, Peoples R China
[2] Ningbo Univ, Inst Hematol, Ningbo, Peoples R China
来源
FRONTIERS IN IMMUNOLOGY | 2024年 / 15卷
关键词
m6A; hematological malignancies; immune microenvironment; immunotherapy; tumor treatment resistance; MESSENGER-RNA; PROMOTES LEUKEMOGENESIS; MYELOID-LEUKEMIA; STEM-CELLS; METHYLATION; CANCER; METHYLTRANSFERASE; PD-1; PROTEIN; N6-METHYLADENOSINE;
D O I
10.3389/fimmu.2024.1374390
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Immunotherapy for hematological malignancies is a rapidly advancing field that has gained momentum in recent years, primarily encompassing chimeric antigen receptor T-cell (CAR-T) therapies, immune checkpoint inhibitors, and other modalities. However, its clinical efficacy remains limited, and drug resistance poses a significant challenge. Therefore, novel immunotherapeutic targets and agents need to be identified. Recently, N6-methyladenosine (m6A), the most prevalent RNA epitope modification, has emerged as a pivotal factor in various malignancies. Reportedly, m6A mutations influence the immunological microenvironment of hematological malignancies, leading to immune evasion and compromising the anti-tumor immune response in hematological malignancies. In this review, we comprehensively summarize the roles of the currently identified m6A modifications in various hematological malignancies, with a particular focus on their impact on the immune microenvironment. Additionally, we provide an overview of the research progress made in developing m6A-targeted drugs for hematological tumor therapy, to offer novel clinical insights.
引用
收藏
页数:13
相关论文
共 50 条
[21]   Characterization of m6A regulator-mediated methylation modification patterns and tumor microenvironment infiltration in acute myeloid leukemia [J].
Han, Shiyu ;
Qi, Jiaqian ;
Fang, Kun ;
Wang, Hong ;
Tang, Yaqiong ;
Wu, Depei ;
Han, Yue .
CANCER MEDICINE, 2022, 11 (05) :1413-1426
[22]   Mechanistic insights into m6A modification of U6 snRNA by human METTL16 [J].
Aoyama, Tomohiko ;
Yamashita, Seisuke ;
Tomita, Kozo .
NUCLEIC ACIDS RESEARCH, 2020, 48 (09) :5157-5168
[23]   N6-methyladenosine (m6A) RNA modification in tumor immunity [J].
Zheng, Siyi ;
Han, Hui ;
Lin, Shuibin .
CANCER BIOLOGY & MEDICINE, 2022, 19 (04) :385-397
[24]   Metabolic Control of m6A RNA Modification [J].
Kim, Joohwan ;
Lee, Gina .
METABOLITES, 2021, 11 (02) :1-11
[25]   Characterization of Modification Patterns, Biological Function, Clinical Implication, and Immune Microenvironment Association of m6A Regulators in Pancreatic Cancer [J].
Fang, Kun ;
Qu, Hairong ;
Wang, Jiapei ;
Tang, Desheng ;
Yan, Changsheng ;
Ma, Jiamin ;
Gao, Lei .
FRONTIERS IN GENETICS, 2021, 12
[26]   Comprehensive analysis of m6A subtype classification for immune microenvironment of pituitary adenomas [J].
Yuan, Feng ;
Cai, Xiangming ;
Wang, Yingshuai ;
Du, Chaonan ;
Cong, Zixiang ;
Zeng, Xinrui ;
Tang, Chao ;
Ma, Chiyuan .
INTERNATIONAL IMMUNOPHARMACOLOGY, 2023, 124
[27]   The Role of m6A Regulator-Mediated Methylation Modification and Tumor Microenvironment Infiltration in Glioblastoma Multiforme [J].
Wang, Liang ;
Cao, Haiyan ;
Zhong, Ying ;
Ji, Peigang ;
Chen, Fan .
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2022, 10
[28]   Effect, Mechanism, and Applications of Coding/Non-coding RNA m6A Modification in Tumor Microenvironment [J].
Si, Chaohua ;
Chen, Chen ;
Guo, Yaxin ;
Kang, Qiaozhen ;
Sun, Zhenqiang .
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2021, 9
[29]   m6A Regulator-Mediated RNA Methylation Modification Patterns Regulate the Immune Microenvironment in Osteoarthritis [J].
Duan, Yang ;
Yu, Cheng ;
Yan, Meiping ;
Ouyang, Yuzhen ;
Ni, Songjia .
FRONTIERS IN GENETICS, 2022, 13
[30]   The significance of m6A RNA methylation modification in prognosis and tumor microenvironment immune infiltration of cervical cancer [J].
Guo, Yilin ;
Bai, Yangyang ;
Wang, Lu ;
Xu, Zhen ;
Wang, Xiliang ;
Wang, Wuliang .
MEDICINE, 2022, 101 (26) :E29818