A new perspective on hematological malignancies: m6A modification in immune microenvironment

被引:3
|
作者
Yang, Shiyu [1 ,2 ]
Xu, Liping [1 ,2 ]
Zhuang, Haihui [1 ,2 ]
Li, Fenglin [1 ,2 ]
Lu, Ying [1 ,2 ]
机构
[1] Ningbo Univ, Affiliated Peoples Hosp, Dept Hematol, Ningbo, Peoples R China
[2] Ningbo Univ, Inst Hematol, Ningbo, Peoples R China
来源
FRONTIERS IN IMMUNOLOGY | 2024年 / 15卷
关键词
m6A; hematological malignancies; immune microenvironment; immunotherapy; tumor treatment resistance; MESSENGER-RNA; PROMOTES LEUKEMOGENESIS; MYELOID-LEUKEMIA; STEM-CELLS; METHYLATION; CANCER; METHYLTRANSFERASE; PD-1; PROTEIN; N6-METHYLADENOSINE;
D O I
10.3389/fimmu.2024.1374390
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Immunotherapy for hematological malignancies is a rapidly advancing field that has gained momentum in recent years, primarily encompassing chimeric antigen receptor T-cell (CAR-T) therapies, immune checkpoint inhibitors, and other modalities. However, its clinical efficacy remains limited, and drug resistance poses a significant challenge. Therefore, novel immunotherapeutic targets and agents need to be identified. Recently, N6-methyladenosine (m6A), the most prevalent RNA epitope modification, has emerged as a pivotal factor in various malignancies. Reportedly, m6A mutations influence the immunological microenvironment of hematological malignancies, leading to immune evasion and compromising the anti-tumor immune response in hematological malignancies. In this review, we comprehensively summarize the roles of the currently identified m6A modifications in various hematological malignancies, with a particular focus on their impact on the immune microenvironment. Additionally, we provide an overview of the research progress made in developing m6A-targeted drugs for hematological tumor therapy, to offer novel clinical insights.
引用
收藏
页数:13
相关论文
共 50 条
  • [1] Role of m6A modification in immune microenvironment of digestive system tumors
    Li, Chao
    Zhu, Mengqi
    Wang, Jiajia
    Wu, Hengshuang
    Liu, Yameng
    Huang, Di
    BIOMEDICINE & PHARMACOTHERAPY, 2023, 164
  • [2] m6A Regulator-Associated Modification Patterns and Immune Infiltration of the Tumor Microenvironment in Hepatocarcinoma
    Li, Jianhao
    Wang, Weiwei
    Zhou, Yubing
    Liu, Liwen
    Zhang, Guizhen
    Guan, Kelei
    Cui, Xichun
    Liu, Xin
    Huang, Maoxin
    Cui, Guangying
    Sun, Ranran
    FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2021, 9
  • [3] A new perspective on Alzheimer's disease: m6A modification
    Xia, Lei
    Zhang, Fan
    Li, Yulu
    Mo, Yuemi
    Zhang, Lingqiu
    Li, Qianhua
    Luo, Minghuang
    Hou, Xiaotao
    Du, Zhengcai
    Deng, Jiagang
    Hao, Erwei
    FRONTIERS IN GENETICS, 2023, 14
  • [4] Characterization of ligamentum flavum hypertrophy based on m6A RNA methylation modification and the immune microenvironment
    He, Zhongyuan
    Zhu, Zhengya
    Tang, Tao
    Guo, Peng
    Gao, Manman
    Li, Baoliang
    Nguyen, Tran Canh Tung
    Chen, Hongkun
    Liu, Xizhe
    Zhou, Zhiyu
    Liu, Shaoyu
    AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH, 2022, 14 (12): : 8800 - +
  • [5] Reshaping the role of m6A modification in cancer transcriptome: a review
    Yang, Guanqun
    Sun, Zhigang
    Zhang, Nan
    CANCER CELL INTERNATIONAL, 2020, 20 (01)
  • [6] The Role of N6-Methyladenosine (m6A) Methylation Modifications in Hematological Malignancies
    Zhao, Yan
    Peng, Hongling
    CANCERS, 2022, 14 (02)
  • [7] M6A regulator-mediated immune infiltration and methylation modification in hepatocellular carcinoma microenvironment and immunotherapy
    Zhao, Kun
    Wei, Bing
    Zhang, Yingxuan
    Shi, Wenkai
    Zhang, Guokun
    Wang, Zhengfeng
    FRONTIERS IN PHARMACOLOGY, 2022, 13
  • [8] M6A Regulatory Genes Play an Important Role in the Prognosis, Progression and Immune Microenvironment of Pancreatic Adenocarcinoma
    Xu, Fangshi
    Zhang, Zhengliang
    Yuan, Miao
    Zhao, Yidi
    Zhou, Yang
    Pei, Honghong
    Bai, Ling
    CANCER INVESTIGATION, 2021, 39 (01) : 39 - 54
  • [9] Comprehensive analysis of m6A RNA methylation modification patterns and the immune microenvironment in osteoarthritis
    Liu, Zhixin
    Liu, Heng
    Li, Deqiang
    Ma, Liang
    Lu, Tongxin
    Sun, Hao
    Zhang, Yuankai
    Yang, Hui
    FRONTIERS IN IMMUNOLOGY, 2023, 14
  • [10] RNA m6A Modification in Immunocytes and DNA Repair: The Biological Functions and Prospects in Clinical Application
    Zhou, Mingjie
    Liu, Wei
    Zhang, Jieyan
    Sun, Nan
    FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2021, 9