Therapeutic Implication of miRNAs as an Active Regulatory Player in the Management of Pain: A Review

被引：3

作者：

Hassan, Mubashir ^{[1
]}

Shahzadi, Saba ^{[1
]}

Yasir, Muhammad ^{[2
]}

Chun, Wanjoo ^{[2
]}

Kloczkowski, Andrzej ^{[1
,3
,4
]}

机构：

[1] Nationwide Childrens Hosp, Steve & Cindy Rasmussen Inst Genom Med, Columbus, OH 43205 USA

[2] Kangwon Natl Univ, Coll Med, Dept Pharmacol, Chunchon 24341, South Korea

[3] Ohio State Univ, Sch Med, Dept Pediat, Columbus, OH 43205 USA

[4] Ohio State Univ, Dept Biomed Informat, Columbus, OH 43210 USA

来源：

GENES | 2024年 / 15卷 / 08期

关键词：

miRNAs; pain; receptor; pain management; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; CENTRAL-NERVOUS-SYSTEM; GROWTH-FACTOR-BETA; NEUROPATHIC PAIN; DOWN-REGULATION; NONCODING RNAS; VISCERAL PAIN; UP-REGULATION; TRANSPORTER EXPRESSION; INFLAMMATORY PAIN;

D O I：

10.3390/genes15081003

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Chronic pain is frequently associated with neuropathy, inflammation, or the malfunctioning of nerves. Chronic pain is associated with a significant burden of morbidity due to opioid use, associated with addiction and tolerance, and disability. MicroRNAs (miRs) are emerging therapeutic targets to treat chronic pain through the regulation of genes associated with inflammation, neuronal excitability, survival, or de-differentiation. In this review, we discuss the possible involvement of miRs in pain-related molecular pathways. miRs are known to regulate high-conviction pain genes, supporting their potential as therapeutic targets.

引用

页数：16

共 168 条

[1] MicroRNAs as Biomarkers of Pain Intensity in Patients With Chronic Fatigue Syndrome [J].

Al-Rawaf, Hadeel A. ;

Alghadir, Ahmad H. ;

Gabr, Sami A. .

PAIN PRACTICE, 2019, 19 (08) :848-860

[2] Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2 [J].

Amir, RE ;

Van den Veyver, IB ;

Wan, M ;

Tran, CQ ;

Francke, U ;

Zoghbi, HY .

NATURE GENETICS, 1999, 23 (02) :185-188

[3]

Ayoub Samir S, 2021, Temperature (Austin), V8, P351, DOI 10.1080/23328940.2021.1886392

[4] Downregulation of selective microRNAs in trigeminal ganglion neurons following inflammatory muscle pain [J].

Bai, Guang ;

Ambalavanar, Rajini ;

Wei, Dong ;

Dessem, Dean .

MOLECULAR PAIN, 2007, 3

[5] Noncoding RNAs: key molecules in understanding and treating pain [J].

Bali, Kiran Kumar ;

Kuner, Rohini .

TRENDS IN MOLECULAR MEDICINE, 2014, 20 (08) :437-448

[6] Immunoprotein-Mediated siRNA Delivery [J].

Balmer, Nicole ;

Berdel, Wolfgang E. ;

Baeumer, Sebastian .

MOLECULAR PHARMACEUTICS, 2017, 14 (05) :1339-1351

[7] Regulation of GABAAReceptor Subunit Expression in Substance Use Disorders [J].

Barker, Jeffrey S. ;

Hines, Rochelle M. .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (12) :1-22

[8]

Barkin R L, 2001, Am J Ther, V8, P433, DOI 10.1097/00045391-200111000-00008

[9] Non-medical use, abuse and dependence on prescription opioids among US adults: Psychiatric, medical and substance use correlates [J].

Becker, William C. ;

Sullivan, Lynn E. ;

Tetrault, Jeanette M. ;

Desai, Rani A. ;

Fiellin, David A. .

DRUG AND ALCOHOL DEPENDENCE, 2008, 94 (1-3) :38-47

[10] Expression of microRNA-146 suppresses NF-κB activity with reduction of metastatic potential in breast cancer cells [J].

Bhaumik, D. ;

Scott, G. K. ;

Schokrpur, S. ;

Patil, C. K. ;

Campisi, J. ;

Benz, C. C. .

ONCOGENE, 2008, 27 (42) :5643-5647

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