Lorlatinib in the treatment of a rare pulmonary mucoepidermoid carcinoma with EML4-ALK fusion: a case report and literature review

被引:0
作者
Xu, Zijun [1 ]
Cong, Xiaofeng [1 ]
Liu, Ziling [1 ]
机构
[1] First Hosp Jilin Univ, Canc Ctr, Changchun, Peoples R China
来源
FRONTIERS IN ONCOLOGY | 2024年 / 14卷
关键词
pulmonary mucoepidermoid carcinoma (PMEC); EML4-ALK fusion; lorlatinib; anaplastic lymphoma kinase-tyrosine kinase inhibitor; first line treatment; LUNG;
D O I
10.3389/fonc.2024.1415254
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Pulmonary mucoepidermoid carcinoma (PMEC) is a rare tumor with limited clinical data available due to its low incidence. So far, there are no universal treatment guidelines for this malignant tumor. We present here the case of a 59-year-old female never smoker who was initially referred to our hospital with cough and hemoptysis and was eventually diagnosed with PMEC. Based on further genetic testing, echinoderm microtubule-associated protein-like4-anaplastic lymphoma kinase (EML4-ALK) fusion variants E20:A20 (V2) was found. The patient was treated with lorlatinib as the first-line treatment. This case is the first to describe the effectiveness of lorlatinib in treating an advanced high-grade PMEC with EML4-ALK fusion V2 mutation patient.
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页数:6
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