Emerging Applications of Nanoparticles in the Diagnosis and Treatment of Breast Cancer

被引:15
作者
Oehler, Josephine B. [1 ,2 ]
Rajapaksha, Weranga [3 ]
Albrecht, Hugo [3 ]
机构
[1] James Cook Univ, Coll Med & Dent, Townsville, Qld 4810, Australia
[2] James Cook Univ, Coll Publ Hlth Med & Vet Sci, Biomed Sci & Mol Biol, Townsville, Qld 4810, Australia
[3] Univ South Australia, Ctr Pharmaceut Innovat CPI, Clin & Hlth Sci, Adelaide, SA 5000, Australia
来源
JOURNAL OF PERSONALIZED MEDICINE | 2024年 / 14卷 / 07期
关键词
breast cancer; tumor; biomarkers; diagnostics; therapeutics; theragnostics; theranostics; nanomedicine; DELIVERY; FORMULATION; CHALLENGES;
D O I
10.3390/jpm14070723
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
Breast cancer remains the most prevalent cancer among women worldwide, driving the urgent need for innovative approaches to diagnosis and treatment. This review highlights the pivotal role of nanoparticles in revolutionizing breast cancer management through advancements of interconnected approaches including targeted therapy, imaging, and personalized medicine. Nanoparticles, with their unique physicochemical properties, have shown significant promise in addressing current treatment limitations such as drug resistance and nonspecific systemic distribution. Applications range from enhancing drug delivery systems for targeted and sustained release to developing innovative diagnostic tools for early and precise detection of metastases. Moreover, the integration of nanoparticles into photothermal therapy and their synergistic use with existing treatments, such as immunotherapy, illustrate their transformative potential in cancer care. However, the journey towards clinical adoption is fraught with challenges, including the chemical feasibility, biodistribution, efficacy, safety concerns, scalability, and regulatory hurdles. This review delves into the current state of nanoparticle research, their applications in breast cancer therapy and diagnosis, and the obstacles that must be overcome for clinical integration.
引用
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页数:18
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