Assessment of environmental and biological stress using mitochondria-targeted red-emitting and near-infrared fluorescent probes for biothiol analysis: a review

被引：4
作者：
Lu, Wen-Yu [1 ]
Li, Hui-Jing [1 ]
Wu, Yan-Chao [1 ]
机构：
[1] Weihai Marine Organism & Med Technol, Harbin Inst Technol, Sch Chem & Chem Engn, Res Inst, Harbin 150006, Peoples R China
来源：
ENVIRONMENTAL CHEMISTRY LETTERS | 2024年 / 22卷 / 06期
基金：
中国国家自然科学基金;
关键词：
Fluorescence probe; Positively charged group; Detection mechanism; Cysteine; Homocysteine; Glutathione; Living cell imaging; HIGHLY SELECTIVE DETECTION; REACTIVE OXYGEN; LIVING CELLS; CYSTEINE; GLUTATHIONE; THIOLS; HOMOCYSTEINE; RELEASE; DYE; LOCALIZATION;
D O I：
10.1007/s10311-024-01761-z
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Levels of biological thiols, or "biothiols," in mitochondria can be used to assess environmental and biological oxidative stress, which can cause health issues such as malignant tumors and neurological diseases. Here, we review fluorescent probes for detecting biothiols, targeting mitochondria, and emitting red and near-infrared light, with focus on nitrogen cation and oxonium ion units as mitochondrial biomarkers. Red-emitting and near-infrared fluorescent probes for detecting biothiols are classified according to the way they target mitochondria. We present the structure, fluorescence behavior, and biological imaging of the probes.
引用
收藏
页码：3135 / 3169
页数：35
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