Synthesis, structure and biological activity of hydrazones derived from 2- and 4-hydroxybenzoic acid hydrazides

The condensation reaction of 4- and 2-hydroxybenzoic acid hydrazides with substituted benzaldehydes led to the formation of a series of hydrazones. The synthesis of hydrazones was carried out successfully in good yields. The structure of compounds was proved by spectral methods. The crystal structures of the methanol solvate of the (E)-N'-[4-(diethylamino)-benzylidene]-4-hydroxybenzohydrazide and the crystalline hydrate of the (E)-N'-[(2-hydroxy-4-diethylamino)-benzylidene]-4-hydroxybenzohydrazide were described with attention to conformational features and hydrogen bonding. The antimicrobial and antiradical activity of hydrazones was studied using molecular docking and in vitro assays.