Tubulointerstitial nephritis with storiform fibrosis in a patient with angioimmunoblastic T-cell lymphoma

被引：0

作者：

Fukuda, Haruka ^{[1
,2
]}

Kitamura, Mineaki ^{[1
,2
]}

Sawase, Atsushi ^{[1
,2
]}

Uramatsu, Tadashi ^{[1
,3
]}

Yamashita, Hiroshi ^{[1
,2
]}

Tsushima, Hideki ^{[4
]}

Irie, Junji ^{[5
]}

Katafuchi, Eisuke ^{[6
]}

Kato, Seiya ^{[7
]}

Takeuchi, Mai ^{[8
]}

Ohshima, Koichi ^{[8
]}

Nakayama, Toshiyuki ^{[6
]}

Mukae, Hiroshi ^{[9
]}

Nishino, Tomoya ^{[1
]}

机构：

[1] Nagasaki Univ, Grad Sch Biomed Sci, Dept Nephrol, 1-7-1 Sakamoto, Nagasaki 8528501, Japan

[2] Nagasaki Harbor Med Ctr, Dept Nephrol, Nagasaki, Japan

[3] Nijigaoka Hosp, Dept Nephrol, Nagasaki, Japan

[4] Nagasaki Harbor Med Ctr, Dept Hematol, Nagasaki, Japan

[5] Nagasaki Harbor Med Ctr, Dept Pathol, Nagasaki, Japan

[6] Univ Occupat & Environm Hlth, Sch Med, Dept Pathol, Kitakyushu, Japan

[7] Saiseikai Fukuoka Gen Hosp, Div Pathol, Fukuoka, Japan

[8] Kurume Univ, Dept Pathol, Kurume, Japan

[9] Nagasaki Univ, Grad Sch Biomed Sci, Dept Resp Med, Nagasaki, Japan

来源：

CEN CASE REPORTS | 2025年 / 14卷 / 01期

关键词：

Angioimmunoblastic T-cell lymphoma; Interstitial nephritis; Storiform fibrosis; Follicular helper T (Tfh) cells; LYMPHADENOPATHY;

D O I：

10.1007/s13730-024-00901-2

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

We present a case of an angioimmunoblastic T-cell lymphoma (AITL) and tubulointerstitial nephritis with storiform fibrosis in a 76-year-old man. The patient exhibited lymphadenopathy, polyclonal hypergammaglobulinemia, and renal dysfunction and was diagnosed with AITL on the basis of lymph node biopsy findings. The serum IgG4 level was highly elevated. Renal biopsy revealed IgG4-positive plasma cells and storiform fibrosis without infiltration of AITL, and the findings indicated IgG4-related kidney disease (IgG4-RKD). Following THPCOP therapy for AITL, the renal function improved. While diagnosing IgG4-RKD in a patient with AITL poses challenges, follicular helper T cell involvement appeared crucial in AITL and renal tubulointerstitial lesions in this case.

引用

页码：39 / 46

页数：8

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