Ocular Tics and Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS)

被引：0
作者：
Dore, Stefano [1 ,2 ]
Satta, Daniele [1 ]
Zinellu, Angelo [3 ]
Boscia, Giacomo [4 ]
Carta, Arturo [5 ]
Fruschelli, Mario [6 ]
Serra, Rita [1 ]
Pinna, Antonio [1 ,2 ]
机构：
[1] Univ Sassari, Dept Med Surg & Pharm, I-07100 Sassari, Italy
[2] Azienda Osped Univ Sassari, Ophthalmol Unit, I-07100 Sassari, Italy
[3] Univ Sassari, Dept Biomed Sci, I-07100 Sassari, Italy
[4] Univ Turin, Dept Ophthalmol, I-10126 Turin, Italy
[5] Univ Parma, Dept Med & Surg, Ophthalmol Unit, I-43126 Parma, Italy
[6] Univ Siena, Dept Med Surg & Neurosci, Ophthalmol Unit, I-53100 Siena, Italy
来源：
DISEASES | 2024年 / 12卷 / 05期
关键词：
oculomotor tics; PANDAS; ASO antibodies; anti-DNase B antibodies; ESR; CRP; SYDENHAM CHOREA; CLINICAL MANAGEMENT; ANTIBODIES; TOURETTE; CHILDREN; TUBULIN; MIMICRY;
D O I：
10.3390/diseases12050083
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Little is known about ocular tics in Pediatric Autoimmune Neuropsychiatric Disorders associated with Streptococcal infections (PANDAS). In this retrospective study, we examined the clinical records of children with motor tics referred to the Ophthalmology Unit, Azienda Ospedaliero-Universitaria di Sassari, Italy, in 2010-2019. The presence of ocular tics was investigated. Data about antistreptolysin O (ASO) and anti-DNase B antibody titers, erythrocyte sedimentation rate (ESR), plasma C-reactive protein (CRP), and antibiotic use were recorded. Forty children (thirty-four boys and six girls; mean age: 7.65 +/- 2.5 years) with motor tics were identified; thirty-three (82.5%) showed ocular tics. Children with ocular tics had significantly higher titers of anti-DNase B antibodies (p = 0.04) and CRP (p = 0.016) than those with extraocular tics. A diagnosis of PANDAS was made in 24 (60%) children. PANDAS children with oculomotor tics had significantly higher titers of anti-DNase B antibodies (p = 0.05) than those with extraocular tics. Oral antibiotics were given to 25/33 (76%) children with ocular tics and 21/24 (87.5%) with PANDAS. All treated patients showed marked improvement/complete resolution of symptoms. Results suggest that higher titers of anti-DNase B antibodies may be implicated in the pathogenesis of ocular tics in PANDAS. Oral antibiotics may be beneficial in improving ocular tics. Further research is necessary to confirm our findings.
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页数：12
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