The Role of Wastewater Treatment Plants in Dissemination of Antibiotic Resistance: Source, Measurement, Removal and Risk Assessment

被引:12
作者
Drane, Kezia [1 ]
Sheehan, Madoc [2 ]
Whelan, Anna [3 ]
Ariel, Ellen [1 ]
Kinobe, Robert [1 ]
机构
[1] James Cook Univ, Coll Publ Hlth Med & Vet Sci, Townsville, Qld 4811, Australia
[2] James Cook Univ, Coll Sci Technol & Engn, Townsville, Qld 4811, Australia
[3] Wastewater Operat, Townsville Water & Waste, Townsville, Qld 4810, Australia
来源
ANTIBIOTICS-BASEL | 2024年 / 13卷 / 07期
关键词
mobile genetic elements; horizontal gene transfer; membrane bioreactor; antimicrobial resistance; sewage processing; environmental pollution; One Health; SEWAGE-TREATMENT PLANT; SUBINHIBITORY CONCENTRATIONS; ANTIMICROBIAL RESIDUES; BACTERIAL COMMUNITIES; AQUATIC ENVIRONMENT; TREATMENT SYSTEMS; EMERGING CONCERN; HEAVY-METALS; GENES; EFFLUENT;
D O I
10.3390/antibiotics13070668
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Antibiotic Resistance Genes (ARGs) are contaminants of emerging concern with marked potential to impact public and environmental health. This review focusses on factors that influence the presence, abundance, and dissemination of ARGs within Wastewater Treatment Plants (WWTPs) and associated effluents. Antibiotic-Resistant Bacteria (ARB) and ARGs have been detected in the influent and the effluent of WWTPs worldwide. Different levels of wastewater treatment (primary, secondary, and tertiary) show different degrees of removal efficiency of ARGs, with further differences being observed when ARGs are captured as intracellular or extracellular forms. Furthermore, routinely used molecular methodologies such as quantitative polymerase chain reaction or whole genome sequencing may also vary in resistome identification and in quantifying ARG removal efficiencies from WWTP effluents. Additionally, we provide an overview of the One Health risk assessment framework, as well as future strategies on how WWTPs can be assessed for environmental and public health impact.
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页数:18
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