The application of retinal organoids in ophthalmic regenerative medicine: A mini-review

被引：1

作者：

Lan, Xinmei ^{[1
]}

Jiang, Huixia ^{[1
]}

Wang, Qian ^{[1
]}

Shiqi, Qin ^{[1
]}

Xiong, Yu ^{[1
]}

机构：

[1] Nanchang Univ, Affiliated Hosp 2, Jiangxi Med Coll, Ophthalm Ctr, Nanchang 330006, Jiangxi, Peoples R China

来源：

REGENERATIVE THERAPY | 2024年 / 26卷

关键词：

Retinal organoids; 3D culture; Cell transplantation; Biomaterials; Regenerative medicine; Glaucoma; Retinal degenerative diseases; GANGLION-CELLS; STEM-CELLS; DIFFERENTIATION; VISION;

D O I：

10.1016/j.reth.2024.06.013

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Retinal organoids are three-dimensional (3D) microscopic tissues that are induced and differentiated from stem cells or progenitor cells in vitro and have a highly similar structure to the retina. With the optimization and development of 3D retinal culture system and the improvement of induced differentiation technology, retinal organoids have broad application prospects in retinal development, regenerative medicine, biomaterial evaluation, disease mechanism investigation, and drug screening. In this review we summarize recent development of retinal organoids and their applications in ophthalmic regenerative medicine. In particular, we highlight the promise and challenges in the use of retinal organoids in disease modeling and drug discovery. (c) 2024 The Author(s). Published by Elsevier BV on behalf of The Japanese Society for Regenerative Medicine. This is an open access article under the CC BY -NC -ND license (http://creativecommons.org/ licenses/by-nc-nd/4.0/).

引用

页码：382 / 386

页数：5

共 42 条

[21] Human retinal organoids with an OPA1 mutation are defective in retinal ganglion cell differentiation and function [J].

Lei, Qiannan ;

Xiang, Kangjian ;

Cheng, Lin ;

Xiang, Mengqing .

STEM CELL REPORTS, 2024, 19 (01) :68-83

[22] Application of patient-derived induced pluripotent stem cells and organoids in inherited retinal diseases [J].

Liang, Yuqin ;

Sun, Xihao ;

Duan, Chunwen ;

Tang, Shibo ;

Chen, Jiansu .

STEM CELL RESEARCH & THERAPY, 2023, 14 (01)

[23] Mesenchymal stem cells, the secretome and biomaterials: Regenerative medicine application [J].

LIM, KI-T A. E. K. ;

V. PATIL, T. E. J. A. L. ;

PATEL, D. I. N. E. S. H. K. ;

DUTTA, S. A. Y. A. N. D. E. B. ;

GANGULY, K. E. Y. A. ;

RANDHAWA, A. A. Y. U. S. H., I .

BIOCELL, 2022, 46 (10) :2201-2208

[24] Retina Organoid Transplants Develop Photoreceptors and Improve Visual Function in RCS Rats With RPE Dysfunction [J].

Lin, Bin ;

McLelland, Bryce T. ;

Aramant, Robert B. ;

Thomas, Biju B. ;

Nistor, Gabriel ;

Keirstead, Hans S. ;

Seiler, Magdalene J. .

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2020, 61 (11)

[25] Re-formation of synaptic connectivity in dissociated human stem cell-derived retinal organoid cultures [J].

Ludwig, Allison L. ;

Mayerl, Steven J. ;

Gao, Yu ;

Banghart, Mark ;

Bacig, Cole ;

Zepeda, Maria A. Fernandez ;

Zhao, Xinyu ;

Gamm, David M. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2023, 120 (02)

[26] Generation of Human Patient iPSC-derived Retinal Organoids to Model Retinitis Pigmentosa [J].

Ma, Chao ;

Jin, Kangxin ;

Jin, Zi-Bing .

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 2022, (184)

[27] Organoids and organ chips in ophthalmology [J].

Manafi, Navid ;

Shokri, Fereshteh ;

Achberger, Kevin ;

Hirayama, Masatoshi ;

Mohammadi, Melika Haji ;

Noorizadeh, Farsad ;

Hong, Jiaxu ;

Liebau, Stefan ;

Tsuji, Takashi ;

Quinn, Peter M. J. ;

Mashaghi, Alireza .

OCULAR SURFACE, 2021, 19 :1-15

[28] Autologous Induced Stem-Cell-Derived Retinal Cells for Macular Degeneration [J].

Mandai, M. ;

Watanabe, A. ;

Kurimoto, Y. ;

Hirami, Y. ;

Morinaga, C. ;

Daimon, T. ;

Fujihara, M. ;

Akimaru, H. ;

Sakai, N. ;

Shibata, Y. ;

Terada, M. ;

Nomiya, Y. ;

Tanishima, S. ;

Nakamura, M. ;

Kamao, H. ;

Sugita, S. ;

Onishi, A. ;

Ito, T. ;

Fujita, K. ;

Kawamata, S. ;

Go, M. J. ;

Shinohara, C. ;

Hata, K. ;

Sawada, M. ;

Yamamoto, M. ;

Ohta, S. ;

Ohara, Y. ;

Yoshida, K. ;

Kuwahara, J. ;

Kitano, Y. ;

Amano, N. ;

Umekage, M. ;

Kitaoka, F. ;

Tanaka, A. ;

Okada, C. ;

Takasu, N. ;

Ogawa, S. ;

Yamanaka, S. ;

Takahashi, M. .

NEW ENGLAND JOURNAL OF MEDICINE, 2017, 376 (11) :1038-1046

[29] iPSC-Derived Retina Transplants Improve Vision in rdl End-Stage Retinal-Degeneration Mice [J].

Mandai, Michiko ;

Fujii, Momo ;

Hashiguchi, Tomoyo ;

Sunagawa, Genshiro A. ;

Ito, Shin-ichiro ;

Sun, Jianan ;

Kaneko, Jun ;

Sho, Junki ;

Yamada, Chikako ;

Takahashi, Masayo .

STEM CELL REPORTS, 2017, 8 (01) :69-83

[30] Tissue engineering of retina through high resolution 3-dimensional inkjet bioprinting [J].

Masaeli, Elahe ;

Forster, Valerie ;

Picaud, Serge ;

Karamali, Fereshte ;

Nasr-Esfahani, Mohammad Hossein ;

Marquette, Christophe .

BIOFABRICATION, 2020, 12 (02)

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