The application of retinal organoids in ophthalmic regenerative medicine: A mini-review

被引：1

作者：

Lan, Xinmei ^{[1
]}

Jiang, Huixia ^{[1
]}

Wang, Qian ^{[1
]}

Shiqi, Qin ^{[1
]}

Xiong, Yu ^{[1
]}

机构：

[1] Nanchang Univ, Affiliated Hosp 2, Jiangxi Med Coll, Ophthalm Ctr, Nanchang 330006, Jiangxi, Peoples R China

来源：

REGENERATIVE THERAPY | 2024年 / 26卷

关键词：

Retinal organoids; 3D culture; Cell transplantation; Biomaterials; Regenerative medicine; Glaucoma; Retinal degenerative diseases; GANGLION-CELLS; STEM-CELLS; DIFFERENTIATION; VISION;

D O I：

10.1016/j.reth.2024.06.013

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Retinal organoids are three-dimensional (3D) microscopic tissues that are induced and differentiated from stem cells or progenitor cells in vitro and have a highly similar structure to the retina. With the optimization and development of 3D retinal culture system and the improvement of induced differentiation technology, retinal organoids have broad application prospects in retinal development, regenerative medicine, biomaterial evaluation, disease mechanism investigation, and drug screening. In this review we summarize recent development of retinal organoids and their applications in ophthalmic regenerative medicine. In particular, we highlight the promise and challenges in the use of retinal organoids in disease modeling and drug discovery. (c) 2024 The Author(s). Published by Elsevier BV on behalf of The Japanese Society for Regenerative Medicine. This is an open access article under the CC BY -NC -ND license (http://creativecommons.org/ licenses/by-nc-nd/4.0/).

引用

页码：382 / 386

页数：5

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