Ontogeny and Function of Plasmacytoid Dendritic Cells

被引：6

作者：

Adams, Nicholas M. ^{[1
]}

Das, Annesa ^{[1
]}

Yun, Tae Jin ^{[1
]}

Reizis, Boris ^{[1
]}

机构：

[1] New York Univ, Dept Pathol, Grossman Sch Med, New York, NY 10012 USA

来源：

ANNUAL REVIEW OF IMMUNOLOGY | 2024年 / 42卷

基金：

美国国家卫生研究院;

关键词：

plasmacytoid dendritic cells; type I interferon; dendritic cells; coronavirus; systemic lupus erythematosus; INTERFERON-PRODUCING CELLS; TRANSCRIPTION FACTOR E2-2; ALPHA-PRODUCING CELLS; VIRUS-INFECTED CELLS; I INTERFERON; PREDENDRITIC CELLS; T-CELLS; VIRAL-INFECTION; RECEPTOR; DIFFERENTIATION;

D O I：

10.1146/annurev-immunol-090122-041105

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Plasmacytoid dendritic cells (pDCs) represent a unique cell type within the innate immune system. Their defining property is the recognition of pathogen-derived nucleic acids through endosomal Toll-like receptors and the ensuing production of type I interferon and other soluble mediators, which orchestrate innate and adaptive responses.We review several aspects of pDC biology that have recently come to the fore. We discuss emerging questions regarding the lineage affiliation and origin of pDCs and argue that these cells constitute an integral part of the dendritic cell lineage. We emphasize the specific function of pDCs as innate sentinels of virus infection, particularly their recognition of and distinct response to virus-infected cells. This essential evolutionary role of pDCs has been particularly important for the control of coronaviruses, as demonstrated by the recent COVID-19 pandemic. Finally, we highlight the key contribution of pDCs to systemic lupus erythematosus, in which therapeutic targeting of pDCs is currently underway.

引用

页码：347 / 373

页数：27

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