The differences between pure and mixed invasive micropapillary breast cancer: the epithelial-mesenchymal transition molecules and prognosis

被引:0
作者
Oz, Ozden [1 ]
Yuzuguldu, Resmiye Irmak [2 ]
Yazici, Ayse [3 ]
Cavdar, Demet Kocatepe [1 ]
Yilmaz, Cengiz [4 ]
Ozturk, Mucteba [5 ]
Duzel, Hilal [6 ]
Gurel, Duygu [7 ]
机构
[1] Univ Hlth Sci, Izmir Bozyaka Training & Res Hosp, Dept Pathol, Izmir, Turkiye
[2] Mugla Training & Res Hosp, Dept Pathol, Mugla, Turkiye
[3] Izmir Katip Celebi Univ, Training & Res Hosp, Fac Med, Dept Pathol, Izmir, Turkiye
[4] Univ Hlth Sci, Izmir Bozyaka Training & Res Hosp, Dept Med Oncol, Izmir, Turkiye
[5] Univ Hlth Sci, Izmir Bozyaka Training & Res Hosp, Dept Gen Surg, Izmir, Turkiye
[6] Dokuz Eylul Univ, Med Fac, Dept Publ Hlth, Izmir, Turkiye
[7] Dokuz Eylul Univ, Med Fac, Dept Pathol, Izmir, Turkiye
关键词
Pure breast micropapillary carcinoma; Epithelial-mesenchymal transition (EMT); Prognostic parameters; Prognosis; CARCINOMA; PROGRESSION; FEATURES; VARIANT;
D O I
10.1007/s10549-024-07384-w
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose Invasive micropapillary carcinoma (IMPC) of the breast is known for its high metastatic potential, but the definition of pure and mixed IMPC remains unclear. This retrospective cohort study aims to investigate the prognostic significance of the micropapillary component ratio and the expression of critical molecules of epithelial-mesenchymal transition (EMT), including E-cadherin (E-cad), N-cadherin (N-cad), CD44s, and beta-catenin (beta-cat), in distinguishing between pure and mixed IMPCs. Methods We analyzed 100 cases of locally advanced IMPC between 2000 and 2018 and excluded patients who received neoadjuvant chemotherapy. Pure IMPC was defined as having a micropapillary component of over 90%. A comprehensive recording of prognostic parameters was conducted. The IMPC areas were analyzed using the immunohistochemical (IHC) staining method on the microarray set for pure and mixed IMPC patients. Pearson's chi-square, Fisher's exact tests, Kaplan-Meier analysis, and Cox proportional hazards analysis were employed. Results The comparative survival analysis of the entire group, based on overall survival (OS) and disease-free survival (DFS), revealed no significant difference between the pure and mixed groups (P = 0.480, HR = 1.474 [0.502-4.325] and P = 0.390, HR = 1.587 [0.550-4.640], respectively). However, in the pure IMPC group, certain factors were found to be associated with a higher risk of short survival. These factors included skin involvement (P = 0.050), pT3&4 category (P = 0.006), a ratio of intraductal component (> 5%) (P = 0.032), and high-level expression of N-cad (P = 0.020). Notably, none of the risk factors identified for short OS in pure IMPC cases were observed as significant risks in mixed cases and vice versa. Furthermore, N-cad was identified as a poor prognostic marker for OS in pure IMPCs (P = 0.002). Conclusion The selection of a 90% ratio for classifying pure IMPCs revealed significant differences in certain molecular and prognostic parameters between pure and mixed groups. Notably, the involvement of N-cadherin in the epithelial-mesenchymal transition (EMT) process provided crucial insights for predicting OS and DFS while also distinguishing between the two groups. These findings strongly support the notion that the pure IMPC subgroup represents a distinct entity characterized by unique molecular characteristics and behavioral patterns.
引用
收藏
页码:41 / 55
页数:15
相关论文
共 50 条
[41]   CDKL2 promotes epithelial-mesenchymal transition and breast cancer progression [J].
Li, Linna ;
Liu, Chunping ;
Amato, Robert J. ;
Chang, Jeffrey T. ;
Du, Guangwei ;
Li, Wenliang .
ONCOTARGET, 2014, 5 (21) :10840-10853
[42]   Vimentin and epithelial-mesenchymal transition in human breast cancer - Observations in vitro and in vivo [J].
Kokkinos, Maria I. ;
Wafai, Razan ;
Wong, Meng Kang ;
Newgreen, Donald F. ;
Thompson, Erik W. ;
Waltham, Mark .
CELLS TISSUES ORGANS, 2007, 185 (1-3) :191-203
[43]   2-Hydroxycinnamaldehyde inhibits the epithelial-mesenchymal transition in breast cancer cells [J].
Ismail Ahmed Ismail ;
Hye Sook Kang ;
Heon-Jin Lee ;
Hyeyoun Chang ;
Jieun Yun ;
Chang Woo Lee ;
Nam Hee Kim ;
Hyun Sil Kim ;
Jong In Yook ;
Su-Hyung Hong ;
Byoung-Mog Kwon .
Breast Cancer Research and Treatment, 2013, 137 :697-708
[44]   Unmasking epithelial-mesenchymal transition in a breast cancer primary culture: A study report [J].
Minafra L. ;
Norata R. ;
Bravatà V. ;
Viola M. ;
Lupo C. ;
Gelfi C. ;
Messa C. .
BMC Research Notes, 5 (1)
[45]   Epithelial cell adhesion molecule and epithelial-mesenchymal transition are associated with vasculogenic mimicry, poor prognosis, and metastasis of triple negative breast cancer [J].
Wu, Qiong ;
Wang, Jingping ;
Liu, Yuanyuan ;
Gong, Xiaomeng .
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 2019, 12 (05) :1678-1689
[46]   Poorly cohesive gastric cancer with increased epithelial-mesenchymal transition is associated with a poor prognosis [J].
Nakazawa, Nobuhiro ;
Sohda, Makoto ;
Ide, Munenori ;
Shimoda, Yuki ;
Sano, Akihiko ;
Sakai, Makoto ;
Oyama, Tetsunari ;
Shirabe, Ken ;
Saeki, Hiroshi .
ONCOLOGY LETTERS, 2024, 28 (03)
[47]   Radiation driven epithelial-mesenchymal transition is mediated by Notch signaling in breast cancer [J].
Kim, Rae-Kwon ;
Kaushik, Neha ;
Suh, Yongjoon ;
Yoo, Ki-Chun ;
Cui, Yan-Hong ;
Kim, Min-Jung ;
Lee, Hae-June ;
Kim, In-Gyu ;
Lee, Su-Jae .
ONCOTARGET, 2016, 7 (33) :53430-53442
[48]   Epithelial to mesenchymal transition (EMT) in metaplastic breast cancer and phyllodes breast tumors [J].
Akrida, Ioanna ;
Mulita, Francesk ;
Plachouri, Kerasia-Maria ;
Benetatos, Nikolaos ;
Maroulis, Ioannis ;
Papadaki, Helen .
MEDICAL ONCOLOGY, 2023, 41 (01)
[49]   High expression of CD47 in triple negative breast cancer is associated with epithelial-mesenchymal transition and poor prognosis [J].
Yuan, Jingping ;
Shi, Xuehui ;
Chen, Chuang ;
He, Huihua ;
Liu, Lin ;
Wu, Juan ;
Yan, Honglin .
ONCOLOGY LETTERS, 2019, 18 (03) :3249-3255
[50]   Classification of epithelial-mesenchymal transition phenotypes in esophageal squamous cell carcinoma is strongly associated with patient prognosis [J].
Sung, Chang Ohk ;
Park, Cheol-Keun ;
Kim, Seok-Hyung .
MODERN PATHOLOGY, 2011, 24 (08) :1060-1068