Granulocytes and mast cells in AllergoOncology-Bridging allergy to cancer: An EAACI position paper

被引：2

作者：

Pascal, Mariona ^{[1
,2
,3
]}

Bax, Heather J. ^{[4
]}

Bergmann, Christoph ^{[5
]}

Bianchini, Rodolfo ^{[6
,7
]}

Castells, Mariana ^{[8
]}

Chauhan, Jitesh ^{[4
]}

De las Vecillas, Leticia ^{[9
]}

Hartmann, Karin ^{[10
,11
]}

Alvarez, Elena Izquierdo ^{[12
]}

Jappe, Uta ^{[13
,14
]}

Jimenez-Rodriguez, Teodorikez-Wilfox ^{[15
]}

Knol, Edward ^{[16
]}

Levi-Schaffer, Francesca ^{[17
]}

Mayorga, Cristobalina ^{[3
,18
]}

Poli, Aurelie ^{[19
]}

Redegeld, Frank ^{[20
]}

Santos, Alexandra F. ^{[21
,22
,23
]}

Jensen-Jarolim, Erika ^{[6
,7
]}

Karagiannis, Sophia N. ^{[4
,24
]}

机构：

[1] Univ Barcelona, Inst Invest Biomed August Pi & Sunyer IDIBAPS, Hosp Clin Barcelona, Dept Immunol,CDB, Barcelona, Spain

[2] Univ Barcelona, Dept Med, Barcelona, Spain

[3] Inst Salud Carlos III ISCIII, RETICS Asma Reacc Adversas & Alerg ARADYAL & RICOR, Madrid, Spain

[4] Kings Coll London, St Johns Inst Dermatol, Sch Basic & Med Biosci & KHP Ctr Translat Med, London, England

[5] RKM740 Interdisciplinary Clin, Dept Otorhinolaryngol, Dusseldorf, Germany

[6] Med Univ Vienna, Inst Pathophysiol & Allergy Res, Ctr Pathophysiol Infectiol & Immunol, Vienna, Austria

[7] Med Univ Vienna, Univ Vet Med Vienna, Interuniv Messerli Res Inst, Vienna, Austria

[8] Harvard Med Sch, Brigham & Womens Hosp, Drug Hypersensit & Desensitizat Ctr, Div Allergy & Clin Immunol,Mastocytosis Ctr, Boston, MA USA

[9] La Paz Univ Hosp, Dept Allergy, IdiPAZ, Madrid, Spain

[10] Univ Basel, Univ Hosp Basel, Dept Dermatol, Div Allergy, Basel, Switzerland

[11] Univ Basel, Univ Hosp Basel, Dept Biomed, Basel, Switzerland

[12] Univ San Pablo CEU, Fac Med, Dept Basic Med Sci, Inst Appl Mol Med,Urbanizac Monteprincipe, Madrid, Spain

[13] German Ctr Lung Res DZL, Res Ctr Borstel, Airway Res Ctr North ARCN, Prior Area Chron Lung Dis, Borstel, Germany

[14] Univ Lubeck, Dept Pneumol, Interdisciplinary Allergy Outpatient Clin, Lubeck, Germany

[15] Dr Balmis Gen Univ Hosp, Alicante Inst Hlth & Biomed Res ISABIAL, Allergy Sect, Alicante, Spain

[16] Univ Med Ctr Utrecht, Ctr Translat Immunol, Utrecht, Netherlands

[17] Hebrew Univ Jerusalem, Inst Drug Res, Fac Med, Sch Pharm, Jerusalem, Israel

[18] Hosp Reg Univ Malaga HRUM, Allergy Unit, Inst Invest Biomed Malaga IBIMA, Allergy Res Grp, Malaga, Spain

[19] Luxembourg Inst Hlth, Dept Canc Res, Neuroimmunol Grp, Luxembourg, Luxembourg

[20] Univ Utrecht, Utrecht Inst Pharmaceut Sci, Fac Sci, Div Pharmacol, Utrecht, Netherlands

[21] Kings Coll London, Fac Life Sci & Med, Sch Life Course Sci, Dept Women & Childrens Hlth Pediatr Allergy, London, England

[22] Kings Coll London, Sch Immunol & Microbial Sci, Peter Gorer Dept Immunobiol, London, England

[23] Evelina London Childrens Hosp, Guys & St Thomas Hosp, Childrens Allergy Serv, London, England

[24] Kings Coll London, Guys Canc Ctr, Sch Canc & Pharmaceut Sci, Breast Canc Now Res Unit, London, England

来源：

ALLERGY | 2024年 / 79卷 / 09期

基金：

英国生物技术与生命科学研究理事会; 英国医学研究理事会; 瑞士国家科学基金会; “创新英国”项目; 欧盟地平线“2020”;

关键词：

AllergoOncology; allergy; basophils; cancer; eosinophils; granulocytes; mast cells; neutrophils; MEDIATED TUMORICIDAL ACTIVITY; COLONY-STIMULATING FACTOR; TO-LYMPHOCYTE RATIO; TUMOR MICROENVIRONMENT; PROGNOSTIC VALUE; EOSINOPHILS; BASOPHILS; NEUTROPHILS; INFILTRATION; ANGIOGENESIS;

D O I：

10.1111/all.16246

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Derived from the myeloid lineage, granulocytes, including basophils, eosinophils, and neutrophils, along with mast cells, play important, often disparate, roles across the allergic disease spectrum. While these cells and their mediators are commonly associated with allergic inflammation, they also exhibit several functions either promoting or restricting tumor growth. In this Position Paper we discuss common granulocyte and mast cell features relating to immunomodulatory functions in allergy and in cancer. We highlight key mechanisms which may inform cancer treatment and propose pertinent areas for future research. We suggest areas where understanding the communication between granulocytes, mast cells, and the tumor microenvironment, will be crucial for identifying immune mechanisms that may be harnessed to counteract tumor development. For example, a comprehensive understanding of allergic and immune factors driving distinct neutrophil states and those mechanisms that link mast cells with immunotherapy resistance, might enable targeted manipulation of specific subpopulations, leading to precision immunotherapy in cancer. We recommend specific areas of investigation in AllergoOncology and knowledge exchange across disease contexts to uncover pertinent reciprocal functions in allergy and cancer and allow therapeutic manipulation of these powerful cell populations. These will help address the unmet needs in stratifying and managing patients with allergic diseases and cancer.

引用

页码：2319 / 2345

页数：27

共 227 条

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