Development of Microneedles for Antimicrobial Drug Delivery: A Comprehensive Review on Applications in Wound Infection Management

Microneedles (MNs) have emerged as a promising transdermal antimicrobial delivery system, providing precise and localized drug delivery while complemented with noninvasiveness and patient compliance. Currently, the topical application of antimicrobials restricts the delivery of drugs to the critical areas of the wound bed, largely due to barriers posed by the necrotic tissue, scab formation, and bacterial biofilms, which severely diminish the bioavailability of the therapeutics. MNs have enabled efficient and targeted delivery to overcome many chronic wound challenges. Over the past decade, significant progress has been made to develop MNs with unique properties tailored for the delivery of vaccines, anticancer, and antimicrobials. As ongoing research continues to refine MN design, material properties, and drug formulations, the potential for revolutionizing antimicrobial drug delivery for efficacy, patient experience, and therapeutic outcomes remains at the forefront of scientific research. In this review, insights are provided into the latest progress, current developments, and the diverse applications of MNs for antimicrobial drug delivery. Herein, the translational potential of MNs is highlighted and a perspective on the current challenges associated with clinical translation is provided. Furthermore, this review aids in identifying research gaps while empowering and contributing to the future implementation of cutting-edge delivery systems to effectively tackle antimicrobial resistance. Infected wounds present a significant challenge in healthcare, leading to prolonged inflammation, heightened pain, impaired healing, and increased mortality. In this review, a critical overview of the design strategies for microneedle antimicrobial drug delivery in context of wound management is provided. In addition, current challenges associated with clinical translation are discussed and research gaps in current knowledge are identified.image (c) 2024 WILEY-VCH GmbH