Immunogenicity of COVID-19 vaccines in patients with follicular lymphoma receiving frontline chemoimmunotherapy

被引：3

作者：

Lim, Yeong Jer ^{[1
,2
]}

Ward, Victoria ^{[3
,4
]}

Brown, Anthony ^{[3
]}

Phillips, Eloise ^{[3
]}

Kronsteiner, Barbara ^{[3
]}

Malone, Tom ^{[3
]}

Jennings, Daisy ^{[3
]}

Healy, Saoirse ^{[3
]}

Longet, Stephanie ^{[3
]}

James, Timothy ^{[5
]}

Thomson, Paul ^{[6
]}

Farrell, Liam ^{[6
]}

Oates, Melanie ^{[1
]}

Jackson, Richard ^{[7
]}

Morrison, Andrew ^{[8
]}

Burns, Matthew ^{[8
]}

Carroll, Miles ^{[3
]}

Klenerman, Paul ^{[3
,9
]}

Turtle, Lance ^{[10
]}

Naisbitt, Dean ^{[6
]}

Rhodes, Malcolm ^{[11
]}

Robinson, Kate ^{[11
]}

Gatto, Simona ^{[12
]}

Young, Moya ^{[13
]}

Linton, Kim ^{[14
,15
]}

Eyre, Toby A. ^{[16
]}

Eyre, David W. ^{[17
]}

Dunachie, Susanna ^{[3
,9
]}

Barnes, Eleanor ^{[3
,9
]}

Pettitt, Andrew ^{[1
,2
]}

机构：

[1] Univ Liverpool, Dept Mol & Clin Canc Med, Liverpool, England

[2] Clatterbridge Canc Ctr NHS Fdn Trust, Liverpool, England

[3] Univ Oxford, Nuffield Dept Med, Oxford, England

[4] Oxford Univ Hosp NHS Fdn Trust, Dept Med Microbiol & Infect Dis, Oxford, England

[5] John Radcliffe Hosp, Dept Clin Biochem, Oxford, England

[6] Univ Liverpool, Dept Pharmacol & Therapeut, Liverpool, England

[7] Univ Liverpool, Dept Hlth Data Sci, Liverpool, England

[8] Univ Liverpool, Liverpool Clin Trials Ctr, Liverpool, England

[9] Oxford Univ Hosp NHS Fdn Trust, NIHR Oxford Biomed Res Ctr, Oxford, England

[10] Univ Liverpool, Dept Clin Infect Microbiol & Immunol, Liverpool, England

[11] Natl Canc Res Inst Consumer Forum, London, England

[12] Cardiff & Vale Univ Hosp Board, Cardiff, Wales

[13] East Kent Hosp Univ NHS Fdn Trust, Ashford, England

[14] Univ Manchester, Manchester, England

[15] Christie NHS Fdn Trust, Manchester, England

[16] Oxford Univ Hosp NHS Fdn Trust, Dept Clin Haematol, Oxford, England

[17] Univ Oxford, Big Data Inst, Nuffield Dept Populat Hlth, Oxford, England

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2024年 / 205卷 / 02期

关键词：

COVID19; follicular lymphoma; lymphoid malignancies; therapy; vaccination; BENDAMUSTINE; RESPONSES; RITUXIMAB; THERAPY; CANCER;

D O I：

10.1111/bjh.19562

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Immune responses to primary COVID-19 vaccination were investigated in 58 patients with follicular lymphoma (FL) as part of the PETReA trial of frontline therapy (EudraCT 2016-004010-10). COVID-19 vaccines (BNT162b2 or ChAdOx1) were administered before, during or after cytoreductive treatment comprising rituximab (depletes B cells) and either bendamustine (depletes CD4+ T cells) or cyclophosphamide-based chemotherapy. Blood samples obtained after vaccine doses 1 and 2 (V1, V2) were analysed for antibodies and T cells reactive to the SARS-CoV-2 spike protein using the Abbott Architect and interferon-gamma ELISpot assays respectively. Compared to 149 healthy controls, patients with FL exhibited lower antibody but preserved T-cell responses. Within the FL cohort, multivariable analysis identified low pre-treatment serum IgA levels and V2 administration during induction or maintenance treatment as independent determinants of lower antibody and higher T-cell responses, and bendamustine and high/intermediate FLIPI-2 score as additional determinants of a lower antibody response. Several clinical scenarios were identified where dichotomous immune responses were estimated with >95% confidence based on combinations of predictive variables. In conclusion, the immunogenicity of COVID-19 vaccines in FL patients is influenced by multiple disease- and treatment-related factors, among which B-cell depletion showed differential effects on antibody and T-cell responses.

引用

页码：440 / 451

页数：12

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