Particulate matter pollution, polygenic risk score and mosaic loss of chromosome Y in middle-aged and older men from the Dongfeng-Tongji cohort study

被引：4

作者：

Guan, Xin ^{[1
]}

Meng, Xia ^{[2
,3
]}

Zhong, Guorong ^{[1
]}

Zhang, Zirui ^{[1
]}

Wang, Chenming ^{[1
]}

Xiao, Yang ^{[1
]}

Fu, Ming ^{[1
]}

Zhao, Hui ^{[1
]}

Zhou, Yuhan ^{[1
]}

Hong, Shiru ^{[1
]}

Xu, Xuedan ^{[1
]}

Bai, Yansen ^{[4
]}

Kan, Haidong ^{[2
,3
]}

Chen, Renjie ^{[2
,3
]}

Wu, Tangchun ^{[1
]}

Guo, Huan ^{[1
,5
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Occupat & Environm Hlth,State Key Lab Environ, 13 Hangkong Rd, Wuhan, Peoples R China

[2] Fudan Univ, Sch Publ Hlth, Dept Environm Hlth, Key Lab Publ Hlth Safety,Minist Educ, Shanghai, Peoples R China

[3] Fudan Univ, Natl Hlth Commiss, Key Lab Hlth Technol Assessment, Shanghai, Peoples R China

[4] Guangzhou Med Univ, Inst Chem Carcinogenesis, Sch Publ Hlth, Guangzhou 511436, Peoples R China

[5] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Occupat & Environm Hlth, 13 Hangkong Rd, Wuhan 430030, Hubei, Peoples R China

来源：

JOURNAL OF HAZARDOUS MATERIALS | 2024年 / 471卷

基金：

中国国家自然科学基金;

关键词：

Mosaic loss of chromosome Y; PM2.5; PM10; Polygenic risk score; Male population; AIR-POLLUTION; OXIDATIVE STRESS; AMBIENT PM2.5; BLOOD; PREDISPOSITION; MORTALITY; EXPOSURE; DISEASE; BURDEN;

D O I：

10.1016/j.jhazmat.2024.134315

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Mosaic loss of chromosome Y (mLOY) is the most common somatic alteration as men aging and may reflect genome instability. PM exposure is a major health concern worldwide, but its effects with genetic factors on mLOY has never been investigated. Here we explored the associations of PM2.5 and PM10 exposure with mLOY of 10,158 males measured via signal intensity of 2186 probes in male-specific chromosome-Y region from Illumina array data. The interactive and joint effects of PM2.5 and PM10 with genetic factors and smoking on mLOY were further evaluated. Compared with the lowest tertiles of PM2.5 levels in each exposure window, the highest tertiles in the same day, 7-, 14-, 21-, and 28-day showed a 0.005, 0.006, 0.007, 0.007, and 0.006 decrease in mLRR-Y, respectively (all P < 0.05), with adjustment for age, BMI, smoking pack-years, alcohol drinking status, physical activity, education levels, season of blood draw, and experimental batch. Such adverse effects were also observed in PM10-mLOY associations. Moreover, the unweighted and weighted PRS presented significant negative associations with mLRR-Y (both P < 0.001). Participants with high PRS and high PM2.5 or PM10 exposure in the 28-day separately showed a 0.018 or 0.019 lower mLRR-Y level [beta (95 %CI) = -0.018 (-0.023, -0.012) and - 0.019 (-0.025, -0.014), respectively, both P < 0.001], when compared to those with low PRS and low PM2.5 or PM10 exposure. We also observed joint effects of PM with smoking on exacerbated mLOY. This large study is the first to elucidate the impacts of PM2.5 exposure on mLOY, and provides key evidence regarding the interactive and joint effects of PM with genetic factors on mLOY, which may promote understanding of mLOY development, further modifying and increasing healthy aging in males.

引用

页数：11

共 70 条

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