Role of MicroRNA in Hypoxic Tumours and their Potential as Biomarkers for Early Detection of Cancer

被引：1
作者：
Jayashree, Pawar [1 ]
Kalpita, Mulye [1 ]
Judith, Talker [1 ]
Singh, Ahirwar Sonu [2 ]
Ashwin, Kotnis [2 ]
机构：
[1] Mumbai Univ, VPMs BN Bandodkar Coll Sci, Dept Biotechnol & Microbiol, Mumbai, Maharashtra, India
[2] All India Inst Med Sci, Dept Biochem, Bhopal 462020, MP, India
来源：
CURRENT MOLECULAR MEDICINE | 2024年 / 24卷 / 05期
关键词：
microRNA; ncRNA; hypoxia; biomarker; cancer; diagnosis; prognosis; CERVICAL-CANCER; COLORECTAL-CANCER; PANCREATIC-CANCER; LIVER-CANCER; PROGNOSIS; PROGRESSION; OVEREXPRESSION; PROLIFERATION; EXPRESSION; DIAGNOSIS;
D O I：
10.2174/0115665240268661231128094831
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Hypoxia is a pathophysiological condition characterized by oxygen deficiency in tissues, which negatively affects normal biological functions. It is a typical microenvironment character of almost all solid tumours. Noncoding RNA are small functional RNA molecules that regulate gene expression at chromatin and post transcriptional levels. Micro-RNAs (miRNAs) are a type of noncoding RNA and are similar to 12-22 nucleotides long that are crucial in regulating gene expression by partnering with the mRNAs of protein-coding genes. It is widely reported that miRs play an important role in various key processes and pathways during tumour formation, as well as advancement in hypoxic tumors by influencing the HIF pathway. The role of miRNAs in hypoxic tumours, namely in pancreatic, kidney, breast, lung and colorectal, are described. These miRNAs have immense potential as diagnostic and prognostic biomarkers for early cancer detection.
引用
收藏
页码：525 / 536
页数：12
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