Decompression Surgery in Elderly Patients with Hemifacial Spasm Refractory to Botulinum Toxin

被引:1
作者
Tugend, Margaret [1 ]
Ulane, Christina M. [2 ]
Patel, Kevin [2 ]
Sekula, Raymond F. [1 ,3 ]
机构
[1] Columbia Univ, Dept Neurol Surg, New York Presbyterian Hosp, Irving Med Ctr, New York, NY USA
[2] Columbia Univ, Irving Med Ctr, New York Presbyterian Hosp, Dept Neurol, New York, NY USA
[3] Columbia Univ, Irving Med Ctr, New York Presbyterian Hosp, New York, NY 10027 USA
关键词
botox; botulinum toxin; elderly; hemifacial spasm; microvascular decompression; treatment refractory; QUALITY-OF-LIFE; MICROVASCULAR DECOMPRESSION; VENOUS THROMBOSIS; SAFETY;
D O I
10.1002/mdc3.14064
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: Botulinum toxin is an effective treatment for hemifacial spasm in elderly patients. However, some patients do not tolerate the side effects and frequency of botulinum toxin treatments. Objectives: The purpose of this study was to evaluate the characteristics and outcomes of a cohort of elderly patients referred by neurologists for surgical decompression of the facial nerve following botulinum toxin treatment. Methods: In a prospective cohort study, logistic regression was used to detect potential predictors of spasm-freedom after surgical decompression of the facial nerve in elderly patients that received <= 8 and >8 botulinum toxin treatments for hemifacial spasm before surgery. Age, sex, side, preoperative symptom duration, and preoperative botulinum toxin treatment were assessed as potential predictors of spasm-freedom at last follow-up. Results: Of 76 elderly patients with hemifacial spasm treated with botulinum toxin and microvascular decompression, with at least 2-years of follow-up (median, 44.5 months), 84.2% were spasm-free at last follow-up. Age (P = 0.38), sex (P = 0.59), side (P = 0.15), preoperative symptom duration (P = 0.7), and number of preoperative botulinum toxin treatments (P = 0.3) were not predictors of long-term spasm-freedom. Permanent ipsilateral hearing loss was the most frequent complication (3.9%). Conclusion: This study provides evidence that elderly patients can undergo botulinum toxin treatment for hemifacial spasm without compromising their likelihood of achieving spasm-freedom with future surgical decompression. Therefore, surgical decompression of the facial nerve is an effective therapy for elderly patients with hemifacial spasm refractory to botulinum toxin.
引用
收藏
页码:966 / 972
页数:7
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