The association between toxicity and efficacy of immune checkpoint inhibitors in older adults with NSCLC

被引：0

作者：

Rong, Yiran ^{[1
]}

Ramachandran, Sujith ^{[2
,3
,4
]}

Bhattacharya, Kaustuv ^{[2
,5
]}

Yang, Yi ^{[2
,4
,6
]}

Earl, Sally ^{[7
]}

Chang, Yunhee ^{[8
]}

Bentley, John P. ^{[3
,4
,9
]}

机构：

[1] Univ Mississippi, Dept Pharm Adm, POB 1848, University, MS 38677 USA

[2] Univ Mississippi, Pharm Adm, POB 1848, University, MS 38677 USA

[3] Univ Mississippi, Ctr Pharmaceut Mkt & Management, POB 1848, University, MS 38677 USA

[4] Univ Mississippi, Res Inst Pharmaceut Sci, POB 1848, University, MS 38677 USA

[5] Univ Mississippi, Ctr Pharmaceut Mkt & Management, Res Inst Pharmaceut Sci, University, MS 38677 USA

[6] Univ Mississippi, Dept Pharm Adm, POB 1848, University, MS 38677 USA

[7] Univ Mississippi, Dept Pharm Practice, Pharm Practice, POB 1848, University, MS 38677 USA

[8] Univ Mississippi, Dept Nutr & Hospitality Management, University, MS 38677 USA

[9] Univ Mississippi, Mkt Joint Appointment, POB 1848, University, MS 38677 USA

来源：

IMMUNOTHERAPY | 2024年 / 16卷 / 16-17期

关键词：

immune-related adverse events; immune checkpoint inhibitors; non-small-cell lung cancer; older adults; survival; CELL LUNG-CANCER; ACUTE KIDNEY INJURY; ADVERSE EVENTS; ADVANCED MELANOMA; IMMUNOTHERAPY; PNEUMONITIS; NIVOLUMAB; OUTCOMES; THERAPY; RISK;

D O I：

10.1080/1750743X.2024.2394382

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Aim: This cohort study evaluated the association between immune checkpoint inhibitors (ICIs)-induced immune-related adverse events (irAEs) and mortality as well as ICI discontinuation among older adults with NSCLC. Methods: 2007-2019 Surveillance, Epidemiology and End Results-Medicare linked database was used and survival analysis with time-varying exposure of irAEs was applied to estimate the associations. Results & conclusion: A total of 8,175 individuals were included, with 46.8% of whom developed an irAE. Cox regression models showed the occurrence of any irAEs was associated with increased risk of mortality (HR: 1.73, 95% CI: 1.63-1.82) and treatment discontinuation (HR: 1.87, 95% CI: 1.78-1.97). Some variability was observed in the effect on the two outcomes depending on the type of irAE.

引用

页码：1057 / 1068

页数：12

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