Transfusion burden in early childhood plays an important role in iron overload in Diamond-Blackfan anaemia

被引：1

作者：

de Wilde, Jonathan R. A. ^{[1
]}

van Dooijeweert, Birgit ^{[1
,2
]}

van Vuren, Annelies J. ^{[3
]}

Huisman, Elise J. ^{[4
]}

Smiers, Frans J. ^{[5
]}

van der Veer, Arian ^{[6
,7
]}

van Wijk, Richard ^{[1
]}

van Solinge, Wouter W. ^{[1
]}

Nieuwenhuis, Edward E. S. ^{[2
]}

van Beers, Eduard J. ^{[3
]}

Bartels, Marije ^{[2
,3
,8
]}

机构：

[1] Univ Utrecht, Univ Med Ctr Utrecht, Cent Diagnost Lab Res, Utrecht, Netherlands

[2] Univ Utrecht, Univ Med Ctr Utrecht, Dept Paediat Haematol, Utrecht, Netherlands

[3] Univ Utrecht, Univ Med Ctr Utrecht, Ctr Benign Haematol Thrombosis & Haemostasis, Van Creveldkliniek, Utrecht, Netherlands

[4] Erasmus MC, Dept Paediat Haematol, Rotterdam, Netherlands

[5] Leiden Univ Med Ctr Leiden, Dept Paediat Haematol, Leiden, Netherlands

[6] Maastricht Univ, Dept Paediat Haematol, Med Ctr, Maastricht, Netherlands

[7] RadboudUMC, Amalia Childrens Hosp, Dept Paediat Haematol, Nijmegen, Netherlands

[8] Heidelberglaan 100, NL-3584 CX Utrecht, Netherlands

来源：

EJHAEM | 2022年 / 3卷 / 04期

关键词：

Diamond-Blackfan anaemia; ferritin; iron overload; liver iron content; GUIDELINES; MANAGEMENT; CHILDREN;

D O I：

10.1002/jha2.524

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In Diamond-Blackfan anaemia (DBA), iron overload (IO) is common in transfusion-dependent patients, yet has also been reported in non-transfusion-dependent patients. We explored the incidence of IO in transfusion-dependent and non-transfusion-dependent DBA patients. We observed hepatic IO in 65% of patients analysed with MRI, including three patients that were only treated with transfusions in the past. Whereas overall ferritin levels and liver iron content correlated, ferritin levels did not reflect total body iron adequately. Our data suggest that transfusion burden in the past plays an important role in IO in DBA, and should be taken into account during follow up.

引用

页码：1300 / 1304

页数：5

共 6 条

[1] Iron overload directly affecting the ovaries in a patient with Diamond-Blackfan anaemia: a case report
Mascarenhas, Mariano
Rawnsley, Victoria
Balen, Adam
HUMAN FERTILITY, 2018, 21 (04) : 294 - 298
[2] Agranulocytosis in patients with Diamond-Blackfan anaemia (DBA) treated with deferiprone for post-transfusion iron overload: A retrospective study of the French DBA cohort
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Castex, Marie-Pierre
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[3] Massive iron overload and acute-on-chronic liver failure in a patient with Diamond-Blackfan anaemia: a case report
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de Almeida Verissimo, Monica Pinheiro
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Seva-Pereira, Tiago
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BMC GASTROENTEROLOGY, 2020, 20 (01)
[4] Central venous catheter thrombosis as a cause of SVC obstruction and cardiac tamponade in a patient with Diamond-Blackfan anemia and iron overload
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PEDIATRIC BLOOD & CANCER, 2006, 46 (01) : 112 - 114
[5] Low regimen-related toxicity and high engraftment including in unrelated donor transplants using fludarabine/treosulfan/thiotepa/alemtuzumab-based conditioning in Diamond Blackfan Anaemia patients with severe iron overload
Elbahy, S.
Bonney, D.
Hiwarkar, P.
Campbell, H.
Wynn, R.
BRITISH JOURNAL OF HAEMATOLOGY, 2018, 181 : 156 - 157
[6] Role of Left Atrial Structure and Function in the Early Prediction of Cardiac Iron Overload in Transfusion-Dependent β-Thalassemia Patients
Parsaee, Mozhgan
Khansari, Nakisa
Azarkeivan, Azita
Chitsazan, Mitra
Ghadrdoost, Behshid
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IRANIAN HEART JOURNAL, 2020, 21 (01): : 27 - 33

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