Adding Fuel to the Fire? The Skin Microbiome in Atopic Dermatitis

被引：3

作者：

Kashaf, Sara Saheb ^{[1
,2
]}

Kong, Heidi H. ^{[3
,4
]}

机构：

[1] Natl Human Genome Res Inst, NIH, Bethesda, MD USA

[2] Univ Chicago, Pritzker Sch Med, Chicago, IL USA

[3] Natl Inst Arthrit & Musculoskeletal & Skin Dis, NIH, Bethesda, MD USA

[4] Natl Inst Arthrit & Musculoskeletal & Skin Dis, Cutaneous Microbiome & Inflammat Sect, Dermatol Branch, NIH, 10 Ctr Dr,Bldg 10,Room 12N240, Bethesda, MD 20892 USA

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2024年 / 144卷 / 05期

基金：

美国国家卫生研究院;

关键词：

Atopic dermatitis; Bacteria; Microbiome; Skin; Staphylococcus; GENOME-WIDE ASSOCIATION; STAPHYLOCOCCUS-AUREUS COLONIZATION; FILAGGRIN MUTATIONS; SUSCEPTIBILITY LOCI; BODY HABITATS; BLEACH BATHS; BARRIER; ECZEMA; INFLAMMATION; CHILDREN;

D O I：

10.1016/j.jid.2024.01.011

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Atopic dermatitis (AD) is a multifactorial, heterogeneous disease characterized by epidermal barrier dysfunction, immune system dysregulation, and skin microbiome alterations. Skin microbiome studies in AD have demonstrated that disease flares are associated with microbial shifts, particularly Staphylococcus differ from those in healthy individuals across various genomic loci, including virulence factors, adhesion proteins, and proinflammatory molecules-which may contribute to complex microbiome barrier-immune system interactions in AD. Different microbially based treatments for AD have been explored, and their future therapeutic successes will depend on a deeper understanding of the potential microbial contributions to the disease.

引用

页码：969 / 977

页数：9

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