Adding Fuel to the Fire? The Skin Microbiome in Atopic Dermatitis

被引:3
作者
Kashaf, Sara Saheb [1 ,2 ]
Kong, Heidi H. [3 ,4 ]
机构
[1] Natl Human Genome Res Inst, NIH, Bethesda, MD USA
[2] Univ Chicago, Pritzker Sch Med, Chicago, IL USA
[3] Natl Inst Arthrit & Musculoskeletal & Skin Dis, NIH, Bethesda, MD USA
[4] Natl Inst Arthrit & Musculoskeletal & Skin Dis, Cutaneous Microbiome & Inflammat Sect, Dermatol Branch, NIH, 10 Ctr Dr,Bldg 10,Room 12N240, Bethesda, MD 20892 USA
基金
美国国家卫生研究院;
关键词
Atopic dermatitis; Bacteria; Microbiome; Skin; Staphylococcus; GENOME-WIDE ASSOCIATION; STAPHYLOCOCCUS-AUREUS COLONIZATION; FILAGGRIN MUTATIONS; SUSCEPTIBILITY LOCI; BODY HABITATS; BLEACH BATHS; BARRIER; ECZEMA; INFLAMMATION; CHILDREN;
D O I
10.1016/j.jid.2024.01.011
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Atopic dermatitis (AD) is a multifactorial, heterogeneous disease characterized by epidermal barrier dysfunction, immune system dysregulation, and skin microbiome alterations. Skin microbiome studies in AD have demonstrated that disease flares are associated with microbial shifts, particularly Staphylococcus differ from those in healthy individuals across various genomic loci, including virulence factors, adhesion proteins, and proinflammatory molecules-which may contribute to complex microbiome barrier-immune system interactions in AD. Different microbially based treatments for AD have been explored, and their future therapeutic successes will depend on a deeper understanding of the potential microbial contributions to the disease.
引用
收藏
页码:969 / 977
页数:9
相关论文
共 122 条
[21]   The role of Malassezia in atopic dermatitis affecting the head and neck of adults [J].
Darabi, Kamruz ;
Hostetler, Sarah Grim ;
Bechtel, Mark A. ;
Zirwas, Matthew .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2009, 60 (01) :125-136
[22]   S. aureus drives itch and scratch-induced skin damage through a V8 protease-PAR1 axis [J].
Deng, Liwen ;
Costa, Flavia ;
Blake, Kimbria J. ;
Choi, Samantha ;
Chandrabalan, Arundhasa ;
Yousuf, Muhammad Saad ;
Shiers, Stephanie ;
Dubreuil, Daniel ;
Vega-Mendoza, Daniela ;
Rolland, Corinne ;
Deraison, Celine ;
Voisin, Tiphaine ;
Bagood, Michelle D. ;
Wesemann, Lucia ;
Frey, Abigail M. ;
Palumbo, Joseph S. ;
Wainger, Brian J. ;
Gallo, Richard L. ;
Leyva-Castillo, Juan-Manuel ;
Vergnolle, Nathalie ;
Price, Theodore J. ;
Ramachandran, Rithwik ;
Horswill, Alexander R. ;
Chiu, Isaac M. .
CELL, 2023, 186 (24) :5375-+
[23]   Inflammatory cytokines and biofilm production sustain Staphylococcus aureus outgrowth and persistence: a pivotal interplay in the pathogenesis of Atopic Dermatitis [J].
Di Domenico, E. G. ;
Cavallo, I. ;
Bordignon, V. ;
Prignano, G. ;
Sperduti, I. ;
Gurtner, A. ;
Trento, E. ;
Toma, L. ;
Pimpinelli, F. ;
Capitanio, B. ;
Ensoli, F. .
SCIENTIFIC REPORTS, 2018, 8
[24]   Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns [J].
Dominguez-Bello, Maria G. ;
Costello, Elizabeth K. ;
Contreras, Monica ;
Magris, Magda ;
Hidalgo, Glida ;
Fierer, Noah ;
Knight, Rob .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (26) :11971-11975
[25]   Genomic analysis reveals different mechanisms of fusidic acid resistance in Staphylococcus aureus from Danish atopic dermatitis patients [J].
Edslev, Sofie Marie ;
Clausen, Maja-Lisa ;
Agner, Tove ;
Stegger, Marc ;
Andersen, Paal Skytt .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2018, 73 (04) :856-861
[26]   High-density genotyping study identifies four new susceptibility loci for atopic dermatitis [J].
Ellinghaus, David ;
Baurecht, Hansjoerg ;
Esparza-Gordillo, Jorge ;
Rodriguez, Elke ;
Matanovic, Anja ;
Marenholz, Ingo ;
Huebner, Norbert ;
Schaarschmidt, Heidi ;
Novak, Natalija ;
Michel, Sven ;
Maintz, Laura ;
Werfel, Thomas ;
Meyer-Hoffert, Ulf ;
Hotze, Melanie ;
Prokisch, Holger ;
Heim, Katharina ;
Herder, Christian ;
Hirota, Omomitsu ;
Tamari, Mayumi ;
Kubo, Michiaki ;
Takahashi, Atsushi ;
Nakamura, Yusuke ;
Tsoi, Lam C. ;
Stuart, Philip ;
Elder, James T. ;
Sun, Liangdan ;
Zuo, Xianbo ;
Yang, Sen ;
Zhang, Xuejun ;
Hoffmann, Per ;
Noethen, Markus M. ;
Foelster-Holst, Regina ;
Winkelmann, Juliane ;
Illig, Thomas ;
Boehm, Bernhard O. ;
Duerr, Richard H. ;
Buening, Carsten ;
Brand, Stephan ;
Glas, Juergen ;
McAleer, Maeve A. ;
Fahy, Caoimhe M. ;
Kabesch, Michael ;
Brown, Sara ;
McLean, W. H. Irwin ;
Irvine, Alan D. ;
Schreiber, Stefan ;
Lee, Young-Ae ;
Franke, Andre ;
Weidinger, Stephan .
NATURE GENETICS, 2013, 45 (07) :808-+
[27]   Stratum corneum lipidomics analysis reveals altered ceramide profile in atopic dermatitis patients across body sites with correlated changes in skin microbiome [J].
Emmert, Hila ;
Baurecht, Hansjoerg ;
Thielking, Frederieke ;
Stoelzl, Dora ;
Rodriguez, Elke ;
Harder, Inken ;
Proksch, Ehrhardt ;
Weidinger, Stephan .
EXPERIMENTAL DERMATOLOGY, 2021, 30 (10) :1398-1408
[28]   A functional IL-6 receptor (IL6R) variant is a risk factor for persistent atopic dermatitis [J].
Esparza-Gordillo, Jorge ;
Schaarschmidt, Heidi ;
Liang, Liming ;
Cookson, William ;
Bauerfeind, Anja ;
Lee-Kirsch, Min-Ae ;
Nemat, Katja ;
Henderson, John ;
Paternoster, Lavinia ;
Harper, John I. ;
Mangold, Elisabeth ;
Nothen, Markus M. ;
Rueschendorf, Franz ;
Kerscher, Tamara ;
Marenholz, Ingo ;
Matanovic, Anja ;
Lau, Susanne ;
Keil, Thomas ;
Bauer, Carl-Peter ;
Kurek, Michael ;
Ciechanowicz, Andrzej ;
Macek, Milan ;
Franke, Andre ;
Kabesch, Michael ;
Hubner, Norbert ;
Abecasis, Goncalo ;
Weidinger, Stephan ;
Moffatt, Miriam ;
Lee, Young-Ae .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2013, 132 (02) :371-377
[29]   A homozygous frameshift mutation in the mouse Flg gene facilitates enhanced percutaneous allergen priming [J].
Fallon, Padraic G. ;
Sasaki, Takashi ;
Sandilands, Aileen ;
Campbell, Linda E. ;
Saunders, Sean P. ;
Mangan, Niamh E. ;
Callanan, John J. ;
Kawasaki, Hiroshi ;
Shiohama, Aiko ;
Kubo, Akiharu ;
Sundberg, John P. ;
Presland, Richard B. ;
Fleckman, Philip ;
Shimizu, Nobuyoshi ;
Kudoh, Jun ;
Irvine, Alan D. ;
Amagai, Masayuki ;
McLean, W. H. Irwin .
NATURE GENETICS, 2009, 41 (05) :602-608
[30]   Clumping Factor B Promotes Adherence of Staphylococcus aureus to Corneocytes in Atopic Dermatitis [J].
Fleury, Orla M. ;
McAleer, Maeve A. ;
Feuillie, Cecile ;
Formosa-Dague, Cecile ;
Sansevere, Emily ;
Bennett, Desiree E. ;
Towell, Aisling M. ;
McLean, W. H. Irwin ;
Kezic, Sanja ;
Robinson, D. Ashley ;
Fallon, Padraic G. ;
Foster, Timothy J. ;
Dufrene, Yves F. ;
Irvine, Alan D. ;
Geoghegan, Joan A. .
INFECTION AND IMMUNITY, 2017, 85 (06)