The Challenge of Examining Social Determinants of Health in People Living With Tourette Syndrome

被引：0

作者：

Dy-Hollins, Marisela E. ^{[1
]}

Carr, Samuel J. ^{[1
,17
]}

Essa, Angela ^{[1
,18
]}

Osiecki, Lisa ^{[1
]}

Lackland, Daniel T. ^{[2
]}

Voeks, Jenifer H. ^{[2
]}

Mejia, Nicte I. ^{[1
]}

Sharma, Nutan ^{[1
]}

Budman, Cathy L. ^{[3
]}

Cath, Danielle C. ^{[4
,5
,6
]}

Grados, Marco A. ^{[7
]}

King, Robert A. ^{[8
]}

Lyon, Gholson J. ^{[9
,10
]}

Rouleau, Guy A. ^{[11
]}

Sandor, Paul ^{[12
]}

Singer, Harvey S. ^{[13
,14
]}

Chibnik, Lori B. ^{[1
,15
]}

Mathews, Carol A. ^{[16
]}

Scharf, Jeremiah M. ^{[1
]}

机构：

[1] Harvard Med Sch, Massachusetts Gen Hosp, Dept Neurol, Boston, MA USA

[2] Med Univ South Carolina, Dept Neurol, Charleston, SC USA

[3] Northwell, Dept Psychiat, New York, NY USA

[4] Univ Med Ctr Groningen, Dept Psychiat, Groningen, Netherlands

[5] Univ Groningen, Groningen, Netherlands

[6] Drenthe Mental Hlth Inst, Groningen, Netherlands

[7] Johns Hopkins Univ, Dept Psychiat & Behav Sci, Sch Med, Baltimore, MD USA

[8] Yale Sch Med, Yale Child Study Ctr, New Haven, CT USA

[9] George A Jervis Clin, Staten Isl, NY USA

[10] Inst Basic Res Dev Disabil, Staten Isl, NY USA

[11] McGill Univ, Hlth Ctr, Montreal Neurol Inst & Hosp, Dept Neurol & Neurosurg, Montreal, PQ, Canada

[12] Univ Toronto, Univ Hlth Network, Dept Psychiat, Toronto, ON, Canada

[13] Johns Hopkins Univ Hosp, Kennedy Krieger Inst, Dept Pediat, Baltimore, MD USA

[14] Johns Hopkins Univ Hosp, Kennedy Krieger Inst, Dept Neurol, Baltimore, MD USA

[15] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA

[16] Univ Florida, Ctr OCD Anxiety & Related Disorders, Dept Psychiat, Gainesville, FL USA

[17] Northeastern Univ, Bouve Coll Hlth Sci, Boston, MA USA

[18] Baystate Med Ctr, Dept Obstet & Gynecol, Springfield, MA USA

来源：

PEDIATRIC NEUROLOGY | 2024年 / 155卷

关键词：

Tourette Syndrome; Disparities; Race; Ethnicity; Social determinants of health; TIC DISORDER; SOCIOECONOMIC-STATUS; PREVALENCE; CHILDREN; EPIDEMIOLOGY; INDIVIDUALS; DISPARITIES; DIAGNOSIS;

D O I：

10.1016/j.pediatrneurol.2024.02.008

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: To examine the association between race, ethnicity, and parental educational attainment on tic-related outcomes among Tourette Syndrome (TS) participants in the Tourette Association of America International Consortium for Genetics (TAAICG) database. Methods: 723 participants in the TAAICG dataset aged <= 21 years were included. The relationships between tic-related outcomes and race and ethnicity were examined using linear and logistic regressions. Parametric and nonparametric tests were performed to examine the association between parental educational attainment and tic-related outcomes. Results: Race and ethnicity were collapsed as non-Hispanic white (N=566, 88.0%) versus Other (N=77, 12.0%). Tic symptom onset was earlier by 1.1 years (P < 0.0001) and TS diagnosis age was earlier by 0.9 years (P = 0.0045) in the Other group (versus non-Hispanic white). Sex and parental education as covariates did not contribute to the differences observed in TS diagnosis age. There were no significant group differences observed across the tic-related outcomes in parental education variable. Conclusions: Our study was limited by the low number of nonwhite or Hispanic individuals in the cohort. Racial and ethnic minoritized groups experienced an earlier age of TS diagnosis than non-Hispanic white individuals. Tic severity did not differ between the two groups, and parental educational attainment did not affect tic-related outcomes. There remain signi ficant disparities and gaps in knowledge regarding TS and associated comorbid conditions. Our study suggests the need for more proactive steps to engage individuals with tic disorders from all racial and ethnic minoritized groups to participate in research studies. (c) 2024 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

引用

页码：55 / 61

页数：7