Profilin affects microtubule dynamics via actin

被引：1

作者：

Ulrichs, Heidi ^{[1
]}

Shekhar, Shashank ^{[1
]}

机构：

[1] Emory Univ, Dept Phys Cell Biol & Biochem, Atlanta, GA 30322 USA

来源：

JOURNAL OF CELL BIOLOGY | 2024年 / 223卷 / 07期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1083/jcb.202404112

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Ulrichs and Shekhar highlight work from Cisterna and colleagues, which reports that microtubule number and stability increases following prolonged depletion of profilin 1 or F-actin due to a loss of actomyosin contractility. Profilin binds microtubules in vitro. However, a new study by Vitriol and colleagues (https://doi.org/10.1083/jcb.202309097) now suggests that effects of profilin on microtubule dynamics in cells are indirect and result from its impact on actin dynamics rather than its direct binding to microtubules.

引用

页数：3

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