Heterogeneity of cancer-associated fibroblasts and tumor-promoting roles in head and neck squamous cell carcinoma

被引:1
作者
El Herch, Imane [1 ,2 ,3 ]
Tornaas, Stian [2 ,3 ]
Dongre, Harsh Nitin [2 ,3 ]
Costea, Daniela Elena [2 ,3 ]
机构
[1] Univ Claude Bernard Lyon 1, Ctr Rech Cancerol Lyon, Univ Lyon, Ctr Leon Berard,CNRS 5286,INSERM 1052, Lyon, France
[2] Univ Bergen, Fac Med & Dent, Dept Clin Med, Gade Lab Pathol, Bergen, Norway
[3] Univ Bergen, Fac Med & Dent, Ctr Canc Biomarkers CCBIO, Bergen, Norway
关键词
cancer-associated fibroblasts; head and neck squamous cell carcinoma; tumor microenvironment; heterogeneity; therapeutic targeting; CHEMOTHERAPY; CETUXIMAB; INVASION;
D O I
10.3389/fmolb.2024.1340024
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Tumor microenvironment (TME) in head and neck squamous cell carcinoma (HNSCC) has a major influence on disease progression and therapy response. One of the predominant stromal cell types in the TME of HNSCC is cancer-associated fibroblasts (CAF). CAF constitute a diverse cell population and we are only at the beginning of characterizing and understanding the functions of various CAF subsets. CAF have been shown to interact with tumor cells and other components of the TME to shape mainly a favourable microenvironment for HNSCC progression, although some studies report existence of tumor-restraining CAF subtypes. The numerous pathways used by CAF to promote tumorigenesis may represent potential therapeutic targets. This review summarizes current knowledge on the origins, subtypes and mechanisms employed by CAF in HNSCC. The aim is to contribute to the understanding on how CAF actively influence the TME and modulate different immune cell types, as well as cancer cells, to establish a conducive setting for cancer growth. Although CAF are currently a promising therapeutic target for the treatment of other types of cancer, there is no significant therapeutic advancement in HNSCC.
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页数:10
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