Perioperative Immunotherapy for Non-Small Cell Lung Cancer: Practical Application of Emerging Data and New Challenges

被引：8

作者：

D'Aiello, Angelica ^{[1
,6
]}

Stiles, Brendon ^{[2
]}

Ohri, Nitin ^{[3
]}

Levy, Benjamin ^{[4
]}

Cohen, Perry ^{[5
]}

Halmos, Balazs ^{[1
,6
]}

机构：

[1] Albert Einstein Coll Med, Montefiore Einstein Comprehens Canc Ctr, Dept Oncol, Bronx, NY USA

[2] Albert Einstein Coll Med, Montefiore Einstein Comprehens Canc Ctr, Div Thorac Surg & Surg Oncol, Bronx, NY USA

[3] Albert Einstein Coll Med, Montefiore Einstein Comprehens Canc Ctr, Dept Radiat Oncol, Bronx, NY USA

[4] Johns Hopkins Univ, Sidney Kimmel Comprehens Canc Ctr, Sch Med, Baltimore, MD USA

[5] Albert Einstein Coll Med, Montefiore Einstein Comprehens Canc Ctr, Dept Pathol, Div Anat & Clin Pathol, Bronx, NY USA

[6] Montefiore Einstein Comprehens Canc Ctr, Dept Oncol, 1695 Eastchester Rd, Bronx, NY 10461 USA

来源：

CLINICAL LUNG CANCER | 2024年 / 25卷 / 03期

关键词：

Adjuvant; Immunotherapy; Lung cancer; NSCLC; Neoadjuvant; NEOADJUVANT ATEZOLIZUMAB; ADJUVANT CHEMOTHERAPY; RADIATION-THERAPY; PLUS CHEMOTHERAPY; OPEN-LABEL; RADIOTHERAPY; PEMBROLIZUMAB; DURVALUMAB; SURGERY; NSCLC;

D O I：

10.1016/j.cllc.2024.02.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Immune checkpoint inhibition, with or without chemotherapy, is an established standard of care for metastatic non-small cell lung cancer (NSCLC). For locally advanced NSCLC treated with chemoradiotherapy, consolidation immunotherapy has dramatically improved outcomes. Recently, immunotherapy has also been established as a valuable component of treatment for resectable NSCLC with pembrolizumab, atezolizumab, and nivolumab all approved for use in this setting. As more results read out from ongoing per ioperative clinical tr ials, navigating treatment options will likely become increasingly complex for the practicing oncologist. In this paper, we distill key outcomes from major perioperative trials and highlight current knowledge gaps. In addition, we provide practical considerations for incorporating perioperative immunotherapy into the clinical management of operable NSCLC.

引用

页码：197 / 214

页数：18

共 77 条

[11] Neoadjuvant chemotherapy plus nivolumab with or without ipilimumab in operable non-small cell lung cancer: the phase 2 platform NEOSTAR trial [J].

Cascone, Tina ;

Leung, Cheuk H. ;

Weissferdt, Annikka ;

Pataer, Apar ;

Carter, Brett W. ;

Godoy, Myrna C. B. ;

Feldman, Hope ;

William Jr, William N. ;

Xi, Yuanxin ;

Basu, Sreyashi ;

Sun, Jing Jing ;

Yadav, Shalini S. ;

Rojas Alvarez, Frank R. ;

Lee, Younghee ;

Mishra, Aditya K. ;

Chen, Lili ;

Pradhan, Monika ;

Guo, Haiping ;

Sinjab, Ansam ;

Zhou, Nicolas ;

Negrao, Marcelo V. ;

Le, Xiuning ;

Gay, Carl M. ;

Tsao, Anne S. ;

Byers, Lauren Averett ;

Altan, Mehmet ;

Glisson, Bonnie S. ;

Fossella, Frank V. ;

Elamin, Yasir Y. ;

Blumenschein, George ;

Zhang, Jianjun ;

Skoulidis, Ferdinandos ;

Wu, Jia ;

Mehran, Reza J. ;

Rice, David C. ;

Walsh, Garrett L. ;

Hofstetter, Wayne L. ;

Rajaram, Ravi ;

Antonoff, Mara B. ;

Fujimoto, Junya ;

Solis, Luisa M. ;

Parra, Edwin R. ;

Haymaker, Cara ;

Wistuba, Ignacio I. ;

Swisher, Stephen G. ;

Vaporciyan, Ara A. ;

Lin, Heather Y. ;

Wang, Jing ;

Gibbons, Don L. ;

Jack Lee, J. .

NATURE MEDICINE, 2023, 29 (3) :593-604

[12] Nodal immune flare mimics nodal disease progression following neoadjuvant immune checkpoint inhibitors in non-small cell lung cancer [J].

Cascone, Tina ;

Weissferdt, Annikka ;

Godoy, Myrna C. B. ;

William, William N., Jr. ;

Leung, Cheuk H. ;

Lin, Heather Y. ;

Basu, Sreashi ;

Yadav, Shalini S. ;

Pataer, Apar ;

Mitchell, Kyle G. ;

Khan, Md Abdul Wadud ;

Shi, Yushu ;

Haymaker, Cara ;

Solis, Luisa M. ;

Parra, Edwin R. ;

Kadara, Huam ;

Wistuba, Ignacio I. ;

Sharma, Padmanee ;

Allison, James P. ;

Ajami, Nadim J. ;

Wargo, Jennifer A. ;

Jenq, Robert R. ;

Gibbons, Don L. ;

Lee, J. Jack ;

Swisher, Stephen G. ;

Vaporciyan, Araa ;

Heymach, John, V ;

Sepesi, Boris .

NATURE COMMUNICATIONS, 2021, 12 (01)

[13] Neoadjuvant nivolumab or nivolumab plus ipilimumab in operable non-small cell lung cancer: the phase 2 randomized NEOSTAR trial [J].

Cascone, Tina ;

William, William N., Jr. ;

Weissferdt, Annikka ;

Leung, Cheuk H. ;

Lin, Heather Y. ;

Pataer, Apar ;

Godoy, Myrna C. B. ;

Carter, Brett W. ;

Federico, Lorenzo ;

Reuben, Alexandre ;

Khan, Md Abdul Wadud ;

Dejima, Hitoshi ;

Francisco-Cruz, Alejandro ;

Parra, Edwin R. ;

Solis, Luisa M. ;

Fujimoto, Junya ;

Tran, Hai T. ;

Kalhor, Neda ;

Fossella, Frank V. ;

Mott, Frank E. ;

Tsao, Anne S. ;

Blumenschein, George, Jr. ;

Le, Xiuning ;

Zhang, Jianjun ;

Skoulidis, Ferdinandos ;

Kurie, Jonathan M. ;

Altan, Mehmet ;

Lu, Charles ;

Glisson, Bonnie S. ;

Byers, Lauren Averett ;

Elamin, Yasir Y. ;

Mehran, Reza J. ;

Rice, David C. ;

Walsh, Garrett L. ;

Hofstetter, Wayne L. ;

Roth, Jack A. ;

Antonoff, Mara B. ;

Kadara, Humam ;

Haymaker, Cara ;

Bernatchez, Chantale ;

Ajami, Nadim J. ;

Jenq, Robert R. ;

Sharma, Padmanee ;

Allison, James P. ;

Futreal, Andrew ;

Wargo, Jennifer A. ;

Wistuba, Ignacio I. ;

Swisher, Stephen G. ;

Lee, J. Jack ;

Gibbons, Don L. .

NATURE MEDICINE, 2021, 27 (03) :504-+

[14] Superior efficacy of neoadjuvant compared to adjuvant immune checkpoint blockade in non-small cell lung cancer [J].

Cascone, Tina ;

Hamdi, Haifa ;

Zhang, Fahao ;

Poteete, Alissa ;

Li, Lerong ;

Hudgens, Courtney W. ;

Williams, Leila J. ;

Wu, Qiuyu ;

Gudikote, Jayanthi ;

Peng, Weiyi ;

Hwu, Patrick ;

Wang, Jing ;

Tetzlaff, Michael ;

William, William N. ;

Heymach, John V. .

CANCER RESEARCH, 2018, 78 (13)

[15] PD-1 Blockade in Mismatch Repair-Deficient, Locally Advanced Rectal Cancer [J].

Cercek, Andrea ;

Lumish, Melissa ;

Sinopoli, Jenna ;

Weiss, Jill ;

Shia, Jinru ;

Lamendola-Essel, Michelle ;

El Dika, Imane H. ;

Segal, Neil ;

Shcherba, Marina ;

Sugarman, Ryan ;

Stadler, Zsofia ;

Yaeger, Rona ;

Smith, J. Joshua ;

Rousseau, Benoit ;

Argiles, Guillem ;

Patel, Miteshkumar ;

Desai, Avni ;

Saltz, Leonard B. ;

Widmar, Maria ;

Iyer, Krishna ;

Zhang, Janie ;

Gianino, Nicole ;

Crane, Christopher ;

Romesser, Paul B. ;

Pappou, Emmanouil P. ;

Paty, Philip ;

Garcia-Aguilar, Julio ;

Gonen, Mithat ;

Gollub, Marc ;

Weiser, Martin R. ;

Schalper, Kurt A. ;

Diaz, Luis A. .

NEW ENGLAND JOURNAL OF MEDICINE, 2022, 386 (25) :2363-2376

[16] Neoadjuvant atezolizumab for resectable non-small cell lung cancer: an open-label, single-arm phase II trial [J].

Chaft, Jamie E. ;

Oezkan, Filiz ;

Kris, Mark G. ;

Bunn, Paul A. ;

Wistuba, Ignacio I. ;

Kwiatkowski, David J. ;

Owen, Dwight H. ;

Tang, Yan ;

Johnson, Bruce E. ;

Lee, Jay M. ;

Lozanski, Gerard ;

Pietrzak, Maciej ;

Seweryn, Michal ;

Byun, Woo Yul ;

Schulze, Katja ;

Nicholas, Alan ;

Johnson, Ann ;

Grindheim, Jessica ;

Hilz, Stephanie ;

Shames, David S. ;

Rivard, Chris ;

Toloza, Eric ;

Haura, Eric B. ;

McNamee, Ciaran J. ;

Patterson, G. Alexander ;

Waqar, Saiama N. ;

Rusch, Valerie W. ;

Carbone, David P. .

NATURE MEDICINE, 2022, 28 (10) :2155-+

[17] Role of Local Radiation Therapy in Cancer Immunotherapy [J].

Demaria, Sandra ;

Golden, Encouse B. ;

Formenti, Silvia C. .

JAMA ONCOLOGY, 2015, 1 (09) :1325-1332

[18] Fractionated but Not Single-Dose Radiotherapy Induces an Immune-Mediated Abscopal Effect when Combined with Anti-CTLA-4 Antibody [J].

Dewan, M. Zahidunnabi ;

Galloway, Ashley E. ;

Kawashima, Noriko ;

Dewyngaert, J. Keith ;

Babb, James S. ;

Formenti, Silvia C. ;

Demaria, Sandra .

CLINICAL CANCER RESEARCH, 2009, 15 (17) :5379-5388

[19]

Durm GA, 2022, J CLIN ONCOL, V40

[20] Neoadjuvant anti-programmed death-1 immunotherapy by pembrolizumab in resectable non-small cell lung cancer: First clinical experience [J].

Eichhorn, Florian ;

Klotz, Laura, V ;

Kriegsmann, Mark ;

Bischoff, Helge ;

Schneider, Marc A. ;

Muley, Thomas ;

Kriegsmann, Katharina ;

Haberkorn, Uwe ;

Heussel, Claus Peter ;

Savai, Rajkumar ;

Zoernig, Inka ;

Jaeger, Dirk ;

Thomas, Michael ;

Hoffmann, Hans ;

Winter, Hauke ;

Eichhorn, Martin E. .

LUNG CANCER, 2021, 153 :150-157

← 1 2 3 4 5 6 7 8 →