Growth inhibition of pancreatic cancer by targeted delivery of gemcitabine via fucoidan-coated pH-sensitive liposomes

被引：2

作者：

Zheng, Zhenjiang ^{[1
]}

Li, Mengfei ^{[2
]}

Yang, Jianchen ^{[5
]}

Zhou, Xintao ^{[2
]}

Chen, Yonghua ^{[1
]}

Silli, Epiphane K. ^{[2
]}

Tang, Jiali ^{[2
]}

Gong, Songlin ^{[1
]}

Yuan, Yuan ^{[1
]}

Zong, Yihao ^{[3
]}

Kong, Jianping ^{[4
]}

Chen, Pu ^{[4
]}

Yu, Lingxi ^{[4
]}

Luo, Shujun ^{[4
]}

Wang, Ying ^{[2
]}

Tan, Chunlu ^{[1
]}

机构：

[1] Sichuan Univ, West China Hosp, Dept Gen Surg, Div Pancreat Surg, Chengdu 610041, Sichuan, Peoples R China

[2] China Pharmaceut Univ, Sch Life Sci & Technol, Nanjing 211198, Jiangsu, Peoples R China

[3] China Pharmaceut Univ, Sch Basic Med & Clin Pharm, Nanjing 211198, Jiangsu, Peoples R China

[4] China Pharmaceut Univ, Sch Pharm, Nanjing 211198, Jiangsu, Peoples R China

[5] Univ Texas Austin, Dept Biomed Engn, Austin, TX 78712 USA

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2024年 / 277卷

关键词：

PH-sensitive liposomes; Pancreatic cancer; Fucoidan; Targeting drug delivery; RECURRENCE; RESECTION; SYSTEM; IONS;

D O I：

10.1016/j.ijbiomac.2024.134517

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Fucoidan-coated pH sensitive liposomes were designed for targeted delivery of gemcitabine (FU-GEM PSL) to treat pancreatic cancer (PC). FU-GEM PSL had a particle size of 175.3 f 4.9 nm, zeta potential of-19.0 f 3.7 mV, encapsulation efficiency (EE) of 74.05 f 0.17%, and drug loading (DL) of 21.27 f 0.05%. Cell experiments in vitro showed that FU-GEM PSL could increase the release of GEM and drug concentration, and could inhibit tumor cell proliferation by affecting the cell cycle. FU-GEM PSL entered cells through macropinocytosis and caveolin-mediated endocytosis to exert effects. Meanwhile, the expression of P-selectin was detected in human tissues, demonstrating the feasibility of targeting FU. Moreover, combined with animal experiments in vivo, FU- GEM PSL could inhibit the development of PC. Furthermore, anti-tumor experiments in vivo carried on BALB/c mice indicated that FU-GEM PSL had tumor suppression abilities and safety. Therefore, FU-GEM PSL is a promising formulation for PC therapy.

引用

页数：13

共 21 条

[21] Thermo- and pH-responsive targeted lipid-coated mesoporous nano silica platform for dual delivery of paclitaxel and gemcitabine to overcome HER2-positive breast cancer
Nasri, Negar
Saharkhiz, Shaghayegh
Dini, Ghasem
Yousefnia, Saghar
[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2023, 648

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