Platelet-rich plasma and plasma rich in growth factors in extra-oral wound care

被引:8
作者
Perussolo, Jeniffer [1 ]
Calciolari, Elena [1 ,2 ]
Dereka, Xanthippi [3 ]
Donos, Nikolaos [1 ]
机构
[1] Queen Mary Univ London, Inst Dent, Fac Med & Dent, Ctr Oral Clin Res, London, England
[2] Univ Parma, Dent Sch, Dept Med & Surg, Parma, Italy
[3] Natl & Kapodistrian Univ Athens, Sch Dent, Dept Periodontol, Dent Sch, Athens, Greece
关键词
extra-oral; healing; plasma rich in growth factors; platelet-rich plasma; wound; THICKNESS SKIN-GRAFT; BED PREPARATION; BURN PATIENTS; DOUBLE-BLIND; LEG ULCERS; GEL; EFFICACY; PREVENTION; THERAPY; INJURY;
D O I
10.1111/prd.12572
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
This narrative review evaluates the existing literature on the clinical efficacy and safety of platelet-rich plasma (PRP) and plasma rich in growth factors (PRGFs) in extra-oral wound care, considering their potential benefits and drawbacks. The review specifically focuses on the impact of these treatments on patients' quality of life, pain management, treatment costs, recurrence rates, and potential complications. Given the extensive literature and diverse range of extra-oral wound types in which these autologous platelet concentrates have been applied, this narrative review focuses on the most frequently described wound types, including diabetic foot ulcers, venous leg ulcers, pressure ulcers, surgical wounds, and burns. The use of PRP has been reported in various medical specialties, with a low risk of adverse events. While there is a growing interest in the use of PRGF with promising results, the available literature on this topic is still limited. Only a few studies evaluated patients' perception of the treatment and the relationship between treatment costs and clinical outcomes. Data on recurrence rates and complications also vary across studies. In conclusion, PRP and PRGF show promise as alternatives or as adjunctive therapies to conventional treatments for various extra-oral wounds and ulcers, leading to reduced wound size and accelerated healing time but should be considered on a case-by-case basis, taking into account the type and severity of the wound.
引用
收藏
页码:320 / 341
页数:22
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