Antiretroviral therapeutic drug monitoring in a patient with small bowel resection and new HIV diagnosis

被引：0

作者：

Ahern, Leigh Cervino ^{[1
]}

Nixon, Daniel ^{[2
]}

Fulco, Patricia Pecora ^{[3
,4
]}

机构：

[1] Johns Hopkins Univ Hosp, Dept Pharm, Baltimore, MD USA

[2] Virginia Commonwealth Univ Hlth, Dept Internal Med, Div Infect Dis, Richmond, VA USA

[3] Virginia Commonwealth Univ Hlth, Div Infect Dis, Dept Pharm, Richmond, VA 23298 USA

[4] Virginia Commonwealth Univ Hlth, Div Infect Dis, Dept Internal Med, Richmond, VA 23298 USA

来源：

IDCASES | 2024年 / 37卷

关键词：

HIV; Antiretroviral therapy; Therapeutic drug monitoring; Small bowel resection; Jejunostomy; DOLUTEGRAVIR;

D O I：

10.1016/j.idcr.2024.e02017

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Antiretroviral (ARV) absorption in persons living with human immunodeficiency virus (PLWH, HIV) with short bowel syndrome is limited. We describe a case of a 28-year-old male with newly diagnosed HIV and plasmablastic lymphoma with proximal jejunostomy necessitating parenteral nutrition. ARV therapy with dolutegravir 50 mg twice daily and once daily tenofovir/emtricitabine was initiated with documented malabsorption and delayed virologic suppression (VS). Dolutegravir dose titration with therapeutic drug monitoring (TDM) resulted in VS at month 12. ARV TDM with dose titration is an option for PLWH with malabsorptive states to maintain VS.

引用

页数：3

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