Association between Transient-Continuous Hypotension during Mechanical Thrombectomy for Acute Ischemic Stroke and Final Infarct Volume in Patients with Proximal Anterior Circulation Large Vessel Occlusion

被引:2
作者
Wiacek, Marcin [1 ,2 ]
Tomaszewska-Lampart, Izabella [1 ,2 ]
Dziedzic, Marzena [2 ]
Kaczorowska, Anna [2 ]
Bartosik-Psujek, Halina [1 ,2 ]
机构
[1] Univ Rzeszow, Inst Med Sci, Dept Neurol, PL-35959 Rzeszow, Poland
[2] Clin Reg Hosp 2, Dept Neurol, PL-35301 Rzeszow, Poland
关键词
acute ischemic stroke; mechanical thrombectomy; hypotension; blood pressure; final infarct volume; large vessel occlusion; BLOOD-PRESSURE; ENDOVASCULAR THROMBECTOMY; ANESTHETIC MANAGEMENT; THERAPY; METAANALYSIS; OUTCOMES;
D O I
10.3390/jcm13133707
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background/Objectives: Periprocedural blood pressure changes in stroke patients with a large vessel occlusion are a known modifiable risk factor of unfavorable treatment outcomes. We aimed to evaluate the association between pre-revascularization hypotension and the final infarct volume. Methods: In our retrospective analysis, we included 214 consecutive stroke patients with an anterior circulation large vessel occlusion that underwent mechanical thrombectomy under general anesthesia. Noninvasively obtained blood pressure values prior to symptomatic vessel recanalization were analyzed as a predictor of post-treatment infarct size. Linear logistic regression models adjusted for predefined factors were used to investigate the association between blood pressure parameters and the final infarct volume. Results: In our cohort, higher baseline systolic blood pressure (a beta = 8.32, 95% CI 0.93-15.7, p = 0.027), its maximal absolute drop (a beta = 6.98, 95% CI 0.42-13.55, p = 0.037), and >40% mean arterial pressure decrease (a beta = 41.77, CI 95% 1.93-81.61, p = 0.040) were independently associated with higher infarct volumes. Similarly, continuous hypotension measured as intraprocedural cumulative time spent below either 100 mmHg (a beta = 3.50 per 5 min, 95% CI 1.49-5.50, p = 0.001) or 90 mmHg mean arterial pressure (a beta = 2.91 per 5 min, 95% CI 0.74-5.10, p = 0.010) was independently associated with a larger ischemia size. In the subgroup analysis of 151 patients with an M1 middle cerebral artery occlusion, two additional factors were independently associated with a larger ischemia size: systolic blood pressure maximal relative drop and >40% drop from pretreatment value (a beta = 1.36 per 1% lower than baseline, 95% CI 0.04-2.67, p = 0.043, and a beta = 43.01, 95% CI 2.89-83.1, p = 0.036, respectively). No associations between hemodynamic parameters and post-treatment infarct size were observed in the cohort of intracranial internal carotid artery occlusion. Conclusions: In patients with ischemic stroke due to a proximal middle cerebral artery occlusion, higher pre-thrombectomy treatment systolic blood pressure is associated with a larger final infarct size. In patients treated under general anesthesia, hypotension prior to the M1 portion of middle cerebral artery recanalization is independently correlated with the post-treatment infarct volume. In this group, every 5 min spent below the mean arterial pressure threshold of 100 mmHg is associated with a 4 mL increase in ischemia volume on a post-treatment NCCT. No associations between blood pressure and final infarct volume were present in the subgroup of patients with an intracranial internal carotid artery occlusion.
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页数:10
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共 27 条
[1]  
Baejewska-Hyorek B., 2019, Pol Przegl Neurol, V15, P1, DOI [10.5603/ppn.2019.0001, DOI 10.5603/PPN.2019.0001, 10.5603/PPN.2019.0001]
[2]   The effect of anesthetic management during intra-arterial therapy for acute stroke in MR CLEAN [J].
Berkhemer, Olvert A. ;
van den Berg, Lucie A. ;
Fransen, Puck S. S. ;
Beumer, Debbie ;
Yoo, Albert J. ;
Lingsma, Hester F. ;
Schonewille, Wouter J. ;
van den Berg, Rene ;
Wermer, Marieke J. H. ;
Boiten, Jelis ;
Nijeholt, Geert J. Lycklama ;
Nederkoorn, Paul J. ;
Hollmann, Markus W. ;
van Zwam, Wim H. ;
van der Lugt, Aad ;
van Oostenbrugge, Robert J. ;
Majoie, Charles B. L. M. ;
Dippel, Diederik W. J. ;
Roos, Yvo B. W. E. M. .
NEUROLOGY, 2016, 87 (07) :656-664
[3]   Automated Cerebral Infarct Volume Measurement in Follow-up Noncontrast CT Scans of Patients with Acute Ischemic Stroke [J].
Boers, A. M. ;
Marquering, H. A. ;
Jochem, J. J. ;
Besselink, N. J. ;
Berkhemer, O. A. ;
van der Lugt, A. ;
Beenen, L. F. ;
Majoie, C. B. .
AMERICAN JOURNAL OF NEURORADIOLOGY, 2013, 34 (08) :1522-1527
[4]   Effect of general anaesthesia on functional outcome in patients with anterior circulation ischaemic stroke having endovascular thrombectomy versus standard care: a meta-analysis of individual patient data [J].
Campbell, Bruce C. V. ;
van Zwam, Wim H. ;
Goyal, Mayank ;
Menon, Bijoy K. ;
Dippel, Diederik W. J. ;
Demchuk, Andrew M. ;
Bracard, Serge ;
White, Philip ;
Davalos, Antoni ;
Majoie, Charles B. L. M. ;
van der Lugt, Aad ;
Ford, Gary A. ;
Perez de la Ossa, Natalia ;
Kelly, Michael ;
Bourcier, Romain ;
Donnan, Geoffrey A. ;
Roos, Yvo B. W. E. M. ;
Bang, Oh Young ;
Nogueira, Raul G. ;
Devlin, Thomas G. ;
van den Berg, Lucie A. ;
Clarencon, Frederic ;
Burns, Paul ;
Carpenter, Jeffrey ;
Berkhemer, Olvert A. ;
Yavagal, Dileep R. ;
Pereira, Vitor Mendes ;
Ducrocq, Xavier ;
Dixit, Anand ;
Quesada, Helena ;
Epstein, Jonathan ;
Davis, Stephen M. ;
Jansen, Olav ;
Rubiera, Marta ;
Urra, Xabier ;
Micard, Emilien ;
Lingsma, Hester F. ;
Naggara, Olivier ;
Brown, Scott ;
Guillemin, Francis ;
Muir, Keith W. ;
van Oostenbrugge, Robert J. ;
Saver, Jeffrey L. ;
Jovin, Tudor G. ;
Hill, Michael D. ;
Mitchell, Peter J. .
LANCET NEUROLOGY, 2018, 17 (01) :47-53
[5]   Anesthetic Management and Outcome in Patients during Endovascular Therapy for Acute Stroke [J].
Davis, Melinda J. ;
Menon, Bijoy K. ;
Baghirzada, Leyla B. ;
Campos-Herrera, Cynthia R. ;
Goyal, Mayank ;
Hill, Michael D. ;
Archer, David P. .
ANESTHESIOLOGY, 2012, 116 (02) :396-404
[6]   Blood pressure management in ischemic stroke patients undergoing mechanical thrombectomy [J].
De Georgia, Michael ;
Bowen, Theodore ;
Duncan, K. Rose ;
Chebl, Alex Bou .
NEUROLOGICAL RESEARCH AND PRACTICE, 2023, 5 (01)
[7]   Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials [J].
Goyal, Mayank ;
Menon, Bijoy K. ;
van Zwam, Wim H. ;
Dippel, Diederik W. J. ;
Mitchell, Peter J. ;
Demchuk, Andrew M. ;
Davalos, Antoni ;
Majoie, Charles B. L. M. ;
van der Lugt, Aad ;
de Miquel, Maria A. ;
Donnan, Geoff Rey A. ;
Roos, Yvo B. W. E. M. ;
Bonafe, Alain ;
Jahan, Reza ;
Diener, Hans-Christoph ;
van den Berg, Lucie A. ;
Levy, Elad I. ;
Berkhemer, Olvert A. ;
Pereira, Vitor M. ;
Rempel, Jeremy ;
Millan, Monica ;
Davis, Stephen M. ;
Roy, Daniel ;
Thornton, John ;
San Roman, Luis ;
Ribo, Marc ;
Beumer, Debbie ;
Stouch, Bruce ;
Brown, Scott ;
Campbell, Bruce C. V. ;
van Oostenbrugge, Robert J. ;
Saver, Jeff Rey L. ;
Hill, Michael D. ;
Jovin, Tudor G. .
LANCET, 2016, 387 (10029) :1723-1731
[8]   Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II) [J].
Hacke, W ;
Kaste, M ;
Fieschi, C ;
von Kummer, R ;
Davalos, A ;
Meier, D ;
Larrue, V ;
Bluhmki, E ;
Davis, S ;
Donnan, G ;
Schneider, D ;
Diez-Tejedor, E ;
Trouillas, P .
LANCET, 1998, 352 (9136) :1245-1251
[9]   Hypotension During Endovascular Treatment of Ischemic Stroke Is a Risk Factor for Poor Neurological Outcome [J].
Henden, Pia Lowhagen ;
Rentzos, Alexandros ;
Karlsson, Jan-Erik ;
Rosengren, Lars ;
Sundeman, Henrik ;
Reinsfelt, Bjorn ;
Ricksten, Sven-Erik .
STROKE, 2015, 46 (09) :2678-2680
[10]   Blood pressure variability and outcomes after mechanical thrombectomy based on the recanalization and collateral status [J].
Huang, Xianjun ;
Guo, Hongquan ;
Yuan, Lili ;
Cai, Qiankun ;
Zhang, Min ;
Zhang, Yi ;
Zhu, Wusheng ;
Li, Zibao ;
Yang, Qian ;
Zhou, Zhiming ;
Sun, Wen ;
Liu, Xinfeng .
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS, 2021, 14