SARS-CoV-2 antibody vaccine response in Inflammatory Bowel Disease patients with positive anti-nucleocapsid serology or history of COVID-19 infection

被引：0

作者：

Hoyois, A. ^{[1
,2
]}

Gulkilik, C. ^{[1
]}

Mekkaoui, L. ^{[3
]}

Dahma, H. ^{[3
]}

Wambacq, V. ^{[1
]}

Minsar, C. ^{[1
]}

Rosewick, N. ^{[4
]}

Liefferinckx, C. ^{[1
]}

Amininejad, L. ^{[1
]}

Van Gossum, A. ^{[1
]}

Cremer, A. ^{[1
]}

Vandenberg, O. ^{[5
]}

Franchimont, D. ^{[1
]}

机构：

[1] Univ Libre Bruxelles, HUB Erasme Hosp, Dept Gastroenterol Hepatopancreatol & Digest Oncol, Brussels, Belgium

[2] Univ Libre Bruxelles, Dept Hepatogastroenterol, CHU St Pierre, Brussels, Belgium

[3] Univ Libre Bruxelles, Dept Microbiol, Lab Hosp Univ Bruxelles Univ Lab Brussel LHUB ULB, Brussels, Belgium

[4] Univ Libre Bruxelles, Lab Expt Gastroenterol, Brussels, Belgium

[5] Univ Libre Bruxelles, Lab Hosp Univ Bruxelles Univ Lab Brussel LHUB ULB, Innovat & Business Dev Unit, Brussels, Belgium

来源：

ACTA GASTRO-ENTEROLOGICA BELGICA | 2024年 / 87卷 / 02期

关键词：

Inflammatory Bowel Disease; COVID-19; vaccine; anti- nucleocapsid antibody; anti-SARS-CoV-2 spike-specific IgG antibody; OUTCOMES; IMPACT;

D O I：

10.51821/87.2.12805

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background: Previous history of COVID-19 infection is a natural booster of the vaccine response in the general population. The response to COVID-19 vaccines is lessened in Inflammatory Bowel Disease patients on selected class of immunosuppressive treatments. Aims: The study was to assess anti-SARS-CoV-2 spike-specific IgG antibody response in Inflammatory Bowel Disease patients with a history of COVID-19 infection. Patients and methods: This single-center prospective study involved 504 Inflammatory Bowel Disease patients. Demographic data and clinical data were gathered through questionnaires and patient charts. Anti-SARS-CoV-2 spike-specific and antinucleocapsid antibody levels were measured at T1, T2 (after the 2-dose series), and T3 or T4 (booster vaccine). Results: This study included 504 Inflammatory Bowel Disease patients, and 234 completed one year follow-up with blood tests. Positive anti-nucleocapsid serology or history of COVID-19 infection was significantly associated with increased median antiSARS-CoV-2 spike-specific IgG titers after the 2-dose series (1930 BAU/mL vs. 521 BAU/mL p < 0.0001) and the booster vaccine (4390 BAU/mL vs. 2160 BAU/mL, p = 0.0156). Multivariate analysis showed that higher anti-SARS-CoV-2 spike-specific IgG levels were independently associated with anti-nucleocapsid antibodies at T2 (OR=2.23, p < 0.0001) and T3 (OR=1.72, p = 0.00011). Immunosuppressive treatments did not impact the antibody response or levels in patients with a history of COVID-19 infection or positive anti-nucleocapsid serology. Conclusions: In Inflammatory Bowel Disease, prior COVID-19 infection or positive anti-nucleocapsid serology leads to increased anti-SARS-CoV-2 spike-specific IgG levels after vaccination, regardless of immunosuppressive treatments. This emphasizes the significance of accounting for previous infection in vaccination approaches. (Acta gastroenterol. belg., 2024, 87, 263-273) )

引用

页码：263 / 273

页数：11

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