Synthetic Modifications of Andrographolide Targeting New Potential Anticancer Drug Candidates: A Comprehensive Overview

被引：1
作者：
Messire, Gatien [1 ]
Rollin, Patrick [1 ]
Gillaizeau, Isabelle [1 ]
Berteina-Raboin, Sabine [1 ]
机构：
[1] Univ Orleans, Inst Chim Organ & Analyt ICOA, UMR CNRS 7311, BP 6759,Rue Chartres, F-45067 Orleans 2, France
来源：
MOLECULES | 2024年 / 29卷 / 12期
关键词：
Andrographis paniculata; andrographolide; synthetic modifications; oncology; drug candidates; IN-VITRO CYTOTOXICITY; BIOLOGICAL EVALUATION; CANCER-CELLS; ANALOGS; DERIVATIVES; POLYSACCHARIDES; INFLAMMATION; APOPTOSIS; AGENTS; PANICULATA;
D O I：
10.3390/molecules29122884
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This review collects the synthetic modifications performed on andrographolide, a natural molecule derived from Andrographis paniculata, for oncology applications. Various pharmacomodulations were carried out, and the products were tested on different cancer cell lines. The impact of these modifications was analyzed with the aim of mapping the positions essential for activity to facilitate future research in this field. However, this study makes it clear that, in addition to structural modifications of the molecule, which can result in varying degrees of effectiveness in targeting interactions, the lipophilic capacity of the structures obtained through hemisynthesis is of significant importance.
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页数：21
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