Cyclodextrin nano-organogels as a delivery vehicle for peppermint essential oil to enhance its physico-chemical properties and skin photoprotective performance

被引：3

作者：

Shalaby, Eman S. ^{[1
]}

Shalaby, Samy I. ^{[2
]}

Taleb, Sally Abou ^{[1
]}

机构：

[1] Natl Res Ctr, Pharmaceut Technol Dept, Giza, Cairo, Egypt

[2] Natl Res Ctr, Anim Hyg Dept, Giza, Cairo, Egypt

来源：

JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY | 2024年

关键词：

peppermint oil; nano-organogels; cyclodextrin; photoprotection; confocal microscopy; skin deposition; NANOSTRUCTURED LIPID CARRIERS; SUN PROTECTION FACTOR; IN-VIVO EVALUATION; TOPICAL DELIVERY; ANTIOXIDANT ACTIVITY; DRUG-DELIVERY; CARNAUBA WAX; VITRO; FORMULATION; SYSTEM;

D O I：

10.1080/01932691.2024.2382253

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Acute sun exposure could lead to erythema and inflammation. This Investigation aims to determine the efficacy of the complexation of peppermint oil (PO) with cyclodextrin in enhancing its physicochemical properties. Nano-organogels were prepared by direct hot melting method. Cyclodextrin (CD) PO was prepared by co-lyophilized method and included in F6. The particle size values were all below 150 nm. F6 polymeric showed high antioxidant activity, in vitro SPF, and stability. CD nano-organogel showed the least release and the highest skin deposition values. This high skin deposition is assured by confocal microscopy. Histology revealed its anti-inflammatory effect against acute UV irradiation. PO CD nano-organogel demonstrates a promising modality for anti-inflammatory therapy against UV irradiation.

引用

页数：13

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