Coupling of surface plasmon resonance and mass spectrometry for molecular interaction studies in drug discovery

被引：6

作者：

Zhao, Yuandi ^{[1
]}

Hadavi, Darya ^{[1
]}

Dijkgraaf, Ingrid ^{[2
,3
]}

Honing, Maarten ^{[1
]}

机构：

[1] Maastricht Univ, Maastricht Multimodal Mol Imaging Inst M4i, Maastricht, Netherlands

[2] Maastricht Univ, Cardiovasc Res Inst Maastricht CARIM, Dept Biochem, Maastricht, Netherlands

[3] MUMC, Dept Radiol & Nucl Med, Maastricht, Netherlands

来源：

DRUG DISCOVERY TODAY | 2024年 / 29卷 / 07期

关键词：

target - ligand interaction; mass spectrometry (MS); surface plasmon resonance (SPR); drug discovery; kinetics; BIOMOLECULAR INTERACTION ANALYSIS; IDENTIFICATION; PROTEINS;

D O I：

10.1016/j.drudis.2024.104027

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Various analytical technologies have been developed for the study of target -ligand interactions. The combination of these technologies gives pivotal information on the binding mechanism, kinetics, af finity, residence time, and changes in molecular structures. Mass spectrometry (MS) offers structural information, enabling the identi fication and quanti fication of target -ligand interactions. Surface plasmon resonance (SPR) provides kinetic information on target -ligand interaction in real time. The coupling of MS and SPR complements each other in the studies of target -ligand interactions. Over the last two decades, the capabilities and added values of SPR-MS have been reported. This review summarizes and highlights the bene fits, applications, and potential for further research of the SPR-MS approach.

引用

页数：8

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