Sex differences in vascular endothelial function related to acute and long COVID-19

被引：4

作者：

Kitselman, A. Kayla ^{[1
]}

Bedard-Matteau, Jerome ^{[2
]}

Rousseau, Simon ^{[2
,3
,4
]}

Tabrizchi, Reza ^{[1
]}

Daneshtalab, Noriko ^{[5
]}

机构：

[1] Mem Univ Newfoundland & Labrador, Fac Med, Div Biomed Sci, St John, NF, Canada

[2] McGill Univ, Fac Med, Dept Pharmacol & Therapeut, Montreal, PQ, Canada

[3] McGill Univ, Expt Med Dept, Fac Med, Montreal, PQ, Canada

[4] RI MUHC, Meakins Christie Labs, Block Eoff EM3 2244Lab E03 21371001 Decarie Blvd, Montreal, PQ H4A 3J1, Canada

[5] Mem Univ Newfoundland & Labrador, Sch Pharm, St John, NF, Canada

来源：

VASCULAR PHARMACOLOGY | 2024年 / 154卷

关键词：

COVID-19; Sex; Myalgic encephalomyelitis-chronic fatigue syndrome; Immune response; Endothelial dysfunction; RENIN-ANGIOTENSIN SYSTEM; GENDER-DIFFERENCES; RISK-FACTORS; DYSFUNCTION; CELLS; ACTIVATION; INFECTION; ACE2;

D O I：

10.1016/j.vph.2023.107250

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus has been at the forefront of health sciences research since its emergence in China in 2019 that quickly led to a global pandemic. As a result of this research, and the large numbers of infected patients globally, there were rapid enhancements made in our understanding of Coronavirus disease 2019 (COVID-19) pathology, including its role in the development of uncontrolled immune responses and its link to the development of endotheliitis and endothelial dysfunction. There were also some noted differences in the rate and severity of infection between males and females with acute COVID. Some individuals infected with SARS-CoV-2 also experience long-COVID, an important hallmark symptom of this being Myalgic Encephalomyelitis-Chronic Fatigue Syndrome (ME-CFS), also experienced differently between males and females. The purpose of this review is to discuss the impact of sex on the vasculature during acute and long COVID-19, present any link between ME-CFS and endothelial dysfunction, and provide evidence for the relationship between ME-CFS and the immune system. We also will delineate biological sex differences observed in other post viral infections and, assess if sex differences exist in how the immune system responds to viral infection causing ME-CFS.

引用

页数：7

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