In vitro anti-breast cancer study of hybrid cinnamic acid derivatives bearing 2-thiohydantoin moiety

被引：2

作者：

Binjawhar, Dalal Nasser ^{[1
]}

Al-Salmi, Fawziah A. ^{[2
]}

Alghamdi, Maha Ali ^{[3
]}

Abu Ali, Ola A. ^{[4
]}

Fayad, Eman ^{[3
]}

Rizzk, Youstina William ^{[5
]}

Ali, Nourhan M. ^{[6
]}

El-Deen, Ibrahim Mohey ^{[7
]}

Eltamany, Elsayed H. ^{[6
]}

机构：

[1] Princess Nourah Bint Abdulrahman Univ, Coll Sci, Dept Chem, POB 84428, Riyadh 11671, Saudi Arabia

[2] Taif Univ, Coll Sci, Biol Dept, POB 11099, Taif 21944, Saudi Arabia

[3] Taif Univ, Coll Sci, Dept Biotechnol, POB 11099, Taif 21944, Saudi Arabia

[4] Taif Univ, Coll Sci, Dept Chem, POB 11099, Taif 21944, Saudi Arabia

[5] Port Said Univ, Fac Sci, Dept Chem, Div Biochem, Port Said, Egypt

[6] Suez Canal Univ, Fac Sci, Dept Chem, Ismailia, Egypt

[7] Port Said Univ, Fac Sci, Dept Chem, Div Organ Chem, Port Said, Egypt

来源：

FUTURE MEDICINAL CHEMISTRY | 2024年 / 16卷 / 16期

关键词：

2-thiohydantoin; anti-breast cancer; caspase-9; cinnamic acid and ester derivatives; Nrf2; topoisomerase II; BIOLOGICAL EVALUATION; THIOHYDANTOIN; INHIBITORS; DESIGN;

D O I：

10.1080/17568919.2024.2366694

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Aim: To synthesize new hybrid cinnamic acids (10a, 10b and 11) and ester derivatives (7, 8 and 9) and investigate their anti-breast cancer activities. Materials & methods: Compounds 7-11 were evaluated (in vitro) for their cytotoxic activities against the MCF-7 cell line. A flow cytometry examination was performed. Protein levels of nuclear factor erythroid 2-related factor 2 (Nrf2), topoisomerase II and caspase-9 were measured by qRT-PCR. Molecular docking studies were conducted. Results: Several components were discovered to be active, mainly component 11, which induced arrest in the cell cycle at phase S, greatly decreased the expression of Nrf2 and topoisomerase II; and upregulated the expression of caspase-9. Conclusion: The newly thiohydantoin-cinnamic acid hybrids can contribute to creating promising candidates for cancer drugs.

引用

页码：1665 / 1684

页数：20

共 60 条

[1] Design, Synthesis and Anticancer Evaluation of Substituted Cinnamic Acid Bearing 2-Quinolone Hybrid Derivatives [J].

Abu Almaaty, Ali H. ;

Elgrahy, Nermeen A. ;

Fayad, Eman ;

Abu Ali, Ola A. ;

Mahdy, Ahmed R. E. ;

Barakat, Lamiaa A. A. ;

El Behery, Mohammed .

MOLECULES, 2021, 26 (16)

[2] In vitro cytotoxic investigation of some synthesized 1,6-disubstituted-1-azacoumarin derivatives as anticancer agents [J].

Ali Barakat, Lamiaa Abellatef ;

El-Deen, Ibrahim Mohy ;

El-Zend, Manar Abdo ;

El-Behery, Mohammed .

FUTURE MEDICINAL CHEMISTRY, 2023, 15 (24) :2289-2307

[3] SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME HYBRID 2-QUINOLINONE DERIVATIVES CONTAINING CINNAMIC ACID AS ANTI-BREAST CANCER DRUGS [J].

Bakare, Safyah B. .

BULLETIN OF THE CHEMICAL SOCIETY OF ETHIOPIA, 2021, 35 (03) :551-564

[4] Vanillin-Based Indolin-2-one Derivative Bearing a Pyridyl Moiety as a Promising Anti-Breast Cancer Agent via Anti-Estrogenic Activity [J].

Bender, Onur ;

Celik, Ismail ;

Dogan, Rumeysa ;

Atalay, Arzu ;

Shoman, Mai E. ;

Ali, Taha F. S. ;

Beshr, Eman A. M. ;

Mohamed, Mahmoud ;

Alaaeldin, Eman ;

Shawky, Ahmed M. ;

Awad, Eman M. ;

Ahmed, Al-Shaimaa F. ;

Younes, Kareem M. ;

Ansari, Mukhtar ;

Anwar, Sirajudheen .

ACS OMEGA, 2023, 8 (07) :6968-6981

[5] Therapeutic Potential of Methotrexate-Loaded Superparamagnetic Iron Oxide Nanoparticles Coated with Poly(lactic-co-glycolic acid) and Polyethylene Glycol against Breast Cancer: Development, Characterization, and Comprehensive In Vitro Investigation [J].

Bhattacharya, Sankha ;

Prajapati, Bhupendra G. ;

Ali, Nemat ;

Mohany, Mohamed ;

Aboul-Soud, Mourad A. M. ;

Khan, Rehan .

ACS OMEGA, 2023, 8 (30) :27634-27649

[6] Molecular and Biological Investigation of Isolated Marine Fungal Metabolites as Anticancer Agents: A Multi-Target Approach [J].

Bogari, Hanin A. ;

Elhady, Sameh S. ;

Darwish, Khaled M. ;

Refaey, Mohamed S. ;

Mohamed, Radi A. ;

Abdelhameed, Reda F. A. ;

Almalki, Ahmad J. ;

Aldurdunji, Mohammed M. ;

Lashkar, Manar O. ;

Alshehri, Samah O. ;

Malatani, Rania T. ;

Yamada, Koji ;

Khedr, Amgad I. M. .

METABOLITES, 2023, 13 (02)

[7] An In Vitro Antimicrobial, Anticancer and Antioxidant Activity of N-[(2-Arylmethylthio)phenylsulfonyl]cinnamamide Derivatives [J].

Bulakowska, Anita ;

Slawinski, Jaroslaw ;

Halasa, Rafal ;

Hering, Anna ;

Gucwa, Magdalena ;

Ochocka, J. Renata ;

Stefanowicz-Hajduk, Justyna .

MOLECULES, 2023, 28 (07)

[8] Polytherapy and Targeted Cancer Drug Resistance [J].

Chatterjee, Nilanjana ;

Bivona, Trever G. .

TRENDS IN CANCER, 2019, 5 (03) :170-182

[9] Recent applications of hydantoin and thiohydantoin in medicinal chemistry [J].

Cho, SeoHyun ;

Kim, Seok-Ho ;

Shin, Dongyun .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 164 :517-545

[10] Cinnamic Acid Derivatives as Anticancer Agents-A Review [J].

De, P. ;

Baltas, M. ;

Bedos-Belval, F. .

CURRENT MEDICINAL CHEMISTRY, 2011, 18 (11) :1672-1703

← 1 2 3 4 5 6 →