Fabrication of polysaccharide-coated oleanolic acid-curcumin-coassembled nanoparticles (OA/Cur NPs): Enhancement of colloidal stability and water solubility

被引：5
作者：
Yan, Linlin [1 ,2 ,3 ,4 ]
Liu, Han [5 ]
Wang, Yuhui [5 ]
Zhang, Lulu [5 ]
Ma, Chao [5 ]
Abd El-Aty, A. M. [6 ,7 ]
机构：
[1] CAF, Inst Chem Ind Forest Prod, Nanjing 210042, Peoples R China
[2] Key Lab Biomass Energy & Mat, Nanjing 210042, Jiangsu, Peoples R China
[3] Natl Forestry & Grassland Adm, Key Lab Chem Engn Forest Prod, Nanjing 210042, Peoples R China
[4] Jiangsu Coinnovat Ctr Efficient Proc & Utilizat Fo, Nanjing 210042, Peoples R China
[5] Beijing Forestry Univ, Coll Biol Sci & Technol, Beijing Key Lab Forest Food Proc & Safety, Beijing 100083, Peoples R China
[6] Cairo Univ, Fac Vet Med, Dept Pharmacol, Giza 12211, Egypt
[7] Ataturk Univ, Fac Med, Dept Med Pharmacol, TR-25240 Erzurum, Turkiye
来源：
FOOD CHEMISTRY | 2024年 / 451卷
基金：
中国国家自然科学基金;
关键词：
Curcumin; Oleanolic acid; Nanoparticle; Colloidal stability; Polysaccharides; Surface coating; CHITOSAN; DELIVERY; CARRIERS; STARCH;
D O I：
10.1016/j.foodchem.2024.139482
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Natural terpenoid carriers, such as oleanolic acid (OA), can enhance the water solubility and stability of hydrophobic compounds such as curcumin (Cur). However, improving the colloidal stability of nanoparticle emulsions and resolving the redispersion problem of freeze-dried nanoparticle powders remain significant challenges. In this study, we fabricated coassembled oleanolic acid-curcumin nanoparticles (OA/Cur NPs) and applied a polysaccharide surface coating method to improve their colloidal stability and water solubility. The results showed that the optimal ratio of Cur/OA for preparing OA/Cur NPs was 4:10, resulting in a high encapsulation efficiency (EE) of Cur (75.2%). Additionally, TEM, contact angle tests, Turbiscan TOWER optical stability analysis of the polysaccharide-coated OA/Cur NP emulsions and redispersion tests of their lyophilized powders verified the advantages of carboxymethyl chitosan/13-cyclodextrin (CMC/13-CD) coating over other polysaccharides. This study indicated that polysaccharide coating is an effective method for enhancing the colloidal stability, water solubility, and redispersibility of OA/Cur NPs.
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页数：10
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