Circulating tumor DNA for monitoring classic Hodgkin lymphoma patients: Correlation with FDG-PET/CT

被引：7

作者：

Fernandez, Sara ^{[1
]}

Cereceda, Laura ^{[1
,2
]}

Diaz, Eva ^{[1
]}

Figueroa, Sasha ^{[1
,2
]}

Reguera, Laura ^{[3
]}

Menendez, Victoria ^{[1
]}

Solorzano, Jose L. ^{[2
]}

Montalban, Carlos ^{[4
]}

Estevez, Monica ^{[4
]}

Garcia, Juan F. ^{[1
,2
,5
]}

机构：

[1] Fdn MD Anderson Int Espana SL Madrid, Translat Res, Madrid, Spain

[2] MD Anderson Canc Ctr Madrid, Pathol Dept, C Arturo Soria 270, Madrid 28033, Spain

[3] MD Anderson Canc Ctr Madrid, Nucl Med Dept, Madrid, Spain

[4] MD Anderson Canc Ctr Madrid, Hematol Dept, Madrid, Spain

[5] ISCIII, Ctr Biomed Network Res Canc CIBERONC, Madrid, Spain

来源：

EJHAEM | 2024年 / 5卷 / 01期

关键词：

Hodgkins lymphoma; lymphoid malignancies; minimal residual disease; MUTATIONS; GENE;

D O I：

10.1002/jha2.826

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The value of circulating tumor DNA (ctDNA) as a biomarker of disease activity in classic Hodgkin lymphoma (cHL) patients has not yet been well established. By profiling primary tumors and ctDNA, we identified common variants between primary tumors and longitudinal plasma samples in most of the cases, confirming high spatial and temporal heterogeneity. Although ctDNA analyses mirrored HRS cell genetics overall, the prevalence of variants shows that none of them can be used as a single biomarker. Conversely, the estimation of hGE/mL, based on measures of total ctDNA, reflects disease activity and is almost perfectly correlated with standard parameters such as PET/CT that are associated with refractoriness.

引用

页码：70 / 75

页数：6

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