The function and therapeutic potential of transfer RNA-derived small RNAs in cardiovascular diseases: A review

被引：6

作者：

Wang, Kai ^{[1
,2
]}

Liu, Cui-Yun ^{[2
]}

Fang, Bo ^{[2
]}

Li, Bo ^{[2
]}

Li, Ying-Hui ^{[2
]}

Xia, Qian-Qian ^{[2
]}

Zhao, Yan ^{[2
]}

Cheng, Xue-Li ^{[2
]}

Yang, Su -Min ^{[3
]}

Zhang, Mei-Hua ^{[1
]}

Wang, Kun ^{[1
,2
]}

机构：

[1] Qingdao Univ, Shandong Prov Maternal & Child Hlth Care Hosp, Key Lab Maternal & Fetal Med Natl Hlth Commiss Chi, Jinan 250014, Peoples R China

[2] Qingdao Univ, Affiliated Hosp, Inst Translat Med, Coll Med, Qingdao 266021, Peoples R China

[3] Qingdao Univ, Affiliated Hosp, Dept Cardiovasc Surg, Qingdao 266003, Peoples R China

来源：

PHARMACOLOGICAL RESEARCH | 2024年 / 206卷

基金：

中国国家自然科学基金;

关键词：

tsRNAs; tRFs; tiRNAs; CVDs; biomarker; therapeutic target; NONCODING RNAS; FRAGMENTS TRFS; ANGIOGENIN; IDENTIFICATION; PROLIFERATION; EXPRESSION; DATABASE; ROLES; HALVES; CELLS;

D O I：

10.1016/j.phrs.2024.107279

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Transfer RNA-derived small RNAs (tsRNAs) are a class of small non-coding RNA (sncRNA) molecules derived from tRNA, including tRNA derived fragments (tRFs) and tRNA halfs (tiRNAs). tsRNAs can affect cell functions by participating in gene expression regulation, translation regulation, intercellular signal transduction, and immune response. They have been shown to play an important role in various human diseases, including cardiovascular diseases (CVDs). Targeted regulation of tsRNAs expression can affect the progression of CVDs. The tsRNAs induced by pathological conditions can be detected when released into the extracellular, giving them enormous potential as disease biomarkers. Here, we review the biogenesis, degradation process and related functional mechanisms of tsRNAs, and discuss the research progress and application prospects of tsRNAs in different CVDs, to provide a new perspective on the treatment of CVDs.

引用

页数：13

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