A Mild Metal-Free Approach for the Direct Synthesis of Carbamoyl Azides from Carboxylic Acid Redox Active Esters

被引：0

作者：

Qiu, Yan-Hua ^{[1
]}

Zhu, Yuping ^{[1
]}

Rao, Ming-Hua ^{[1
]}

Huang, Chang-Qi ^{[1
]}

Huang, Zi-Ying ^{[1
]}

Chen, Zhengwang ^{[1
]}

Zhu, Jinbin ^{[1
]}

Yu, Daohong ^{[1
]}

机构：

[1] Gannan Normal Univ, Key Lab Key Lab Organo Pharmaceut Chem Jiangxi Pro, Ganzhou 34100, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2024年 / 366卷 / 12期

基金：

中国国家自然科学基金;

关键词：

Carbamoyl azide; Redox active ester; Metal free; Oxidant free; ACYL AZIDES; C-C; UREAS; ALDEHYDES;

D O I：

10.1002/adsc.202301498

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Carbamoyl azide is a pivotal compound used in the transformation into urea and amines, as well as in nitrene insertion reactions. In this study, we present a pioneering method for synthesizing carbamoyl azide directly from acid redox active esters without the use of metals or oxidants. This approach demonstrates tolerance for various functional groups, enhancing its applicability. Furthermore, this technique facilitates late-stage modifications of natural products and pharmaceuticals, thereby accelerating the development and identification of novel drug candidates. image

引用

页码：2678 / 2683

页数：6

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