Cariprazine maintenance treatment during pregnancy - a case report

被引：0

作者：

Herold, Robert ^{[1
]}

Tenyi, Tamas ^{[1
]}

Herold, Marton ^{[1
]}

Toth, Tunde ^{[2
]}

机构：

[1] Univ Pecs, Med Sch, Dept Psychiat & Psychotherapy, Pecs, Hungary

[2] Markhot Ferenc Teaching Hosp & Clin, Psychiat Outpatient Dept, Eger, Hungary

来源：

FRONTIERS IN PSYCHIATRY | 2024年 / 15卷

关键词：

pregnancy; antipsychotics; cariprazine; schizophrenia; case report; SCHIZOPHRENIA;

D O I：

10.3389/fpsyt.2024.1421395

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Data on reproductive safety of recently approved newer antipsychotics are limited. Here, we report a case vignette of a patient with schizophrenia treated with cariprazine during pregnancy. The patient became pregnant unexpectedly while taking medication. As a result of shared decision-making, the patient and her psychiatrist decided to continue the treatment, which proved to be protective against relapse and had no adverse effect either on the course of pregnancy or on the health of the newborn. Cariprazine maintenance treatment during pregnancy was found to be safe in our case.

引用

页数：4

共 12 条

[1] Gestational and Neurodevelopmental Outcomes Associated With Antipsychotic Drug Exposure During Pregnancy [J].

Andrade, Chittaranjan .

JOURNAL OF CLINICAL PSYCHIATRY, 2021, 82 (05)

[2] Evidence-based guidelines for the pharmacological treatment of schizophrenia: Updated recommendations from the British Association for Psychopharmacology [J].

Barnes, Thomas R. E. ;

Drake, Richard ;

Paton, Carol ;

Cooper, Stephen J. ;

Deakin, Bill ;

Ferrier, I. Nicol ;

Gregory, Catherine J. ;

Haddad, Peter M. ;

Howes, Oliver D. ;

Jones, Ian ;

Joyce, Eileen M. ;

Lewis, Shon ;

Lingford-Hughes, Anne ;

MacCabe, James H. ;

Owensm, David Cunningham ;

Patel, Maxine X. ;

Sinclair, Julia M. A. ;

Stone, James M. ;

Talbot, Peter S. ;

Upthegrove, Rachel ;

Wieck, Angelika ;

Yung, Alison R. .

JOURNAL OF PSYCHOPHARMACOLOGY, 2020, 34 (01) :3-78

[3] Use of Antipsychotic Drugs During Pregnancy [J].

Betcher H.K. ;

Montiel C. ;

Clark C.T. .

Current Treatment Options in Psychiatry, 2019, 6 (1) :17-31

[4] Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for the management of schizophrenia and related disorders [J].

Galletly, Cherrie ;

Castle, David ;

Dark, Frances ;

Humberstone, Verity ;

Jablensky, Assen ;

Killackey, Eoin ;

Kulkarni, Jayashri ;

McGorry, Patrick ;

Nielssen, Olav ;

Tran, Nga .

AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY, 2016, 50 (05) :410-472

[5] Maternal cariprazine exposure inhibits embryonic and postnatal brain cholesterol biosynthesis [J].

Genaro-Mattos, Thiago C. ;

Anderson, Allison ;

Allen, Luke B. ;

Tallman, Keri A. ;

Porter, Ned A. ;

Korade, Zeljka ;

Mirnics, Karoly .

MOLECULAR PSYCHIATRY, 2020, 25 (11) :2685-2694

[6] Association of In Utero Antipsychotic Medication Exposure With Risk of Congenital Malformations in Nordic Countries and the US [J].

Huybrechts, Krista F. ;

Straub, Loreen ;

Karlsson, Par ;

Pazzagli, Laura ;

Furu, Kari ;

Gissler, Mika ;

Hernandez-Diaz, Sonia ;

Norgaard, Mette ;

Zoega, Helga ;

Bateman, Brian T. ;

Cesta, Carolyn E. ;

Cohen, Jacqueline M. ;

Leinonen, Maarit K. ;

Reutfors, Johan ;

Selmer, Randi M. ;

Suarez, Elizabeth A. ;

Ulrichsen, Sinna Pilgaard ;

Kieler, Helle .

JAMA PSYCHIATRY, 2023, 80 (02) :156-166

[7]

Keepers GA, 2020, AM J PSYCHIAT, V177, P868, DOI [10.1176/appi.focus.18402, 10.1176/appi.ajp.2020.177901]

[8] Cariprazine (RGH-188), a Dopamine D3 Receptor-Preferring, D3/D2 Dopamine Receptor Antagonist-Partial Agonist Antipsychotic Candidate: In Vitro and Neurochemical Profile [J].

Kiss, Bela ;

Horvath, Attila ;

Nemethy, Zsolt ;

Schmidt, Eva ;

Laszlovszky, Istvan ;

Bugovics, Gyula ;

Fazekas, Karoly ;

Hornok, Katalin ;

Orosz, Szabolcs ;

Gyertyan, Istvan ;

Agai-Csongor, Eva ;

Domany, Gyoergy ;

Tihanyi, Karoly ;

Adham, Nika ;

Szombathelyi, Zsolt .

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2010, 333 (01) :328-340

[9] Medication effects on developmental sterol biosynthesis [J].

Korade, Zeljka ;

Heffer, Marija ;

Mirnics, Karoly .

MOLECULAR PSYCHIATRY, 2022, 27 (01) :490-501

[10]

Németh G, 2017, LANCET, V389, P1103, DOI [10.1016/s0140-6736(17)30060-0, 10.1016/S0140-6736(17)30060-0]

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