Adenosine and Its Receptors in the Pathogenesis and Treatment of Inflammatory Skin Diseases

被引:7
作者
Chen, Luxia [1 ]
Lei, Xuan [1 ]
Mahnke, Karsten [1 ]
机构
[1] Univ Hosp Heidelberg, Dept Dermatol, Neuenheimer Feld 440, D-69120 Heidelberg, Germany
关键词
adenosine receptors; inflammation; psoriasis; hyperplasia; immunosuppression; PLAQUE-TYPE PSORIASIS; ORAL CF101 DATA; MOUSE MODEL; KERATINOCYTE PROLIFERATION; INTERNATIONAL UNION; TOPICAL APPLICATION; A(2B) RECEPTORS; IL-6; PRODUCTION; GLUCOSE-UPTAKE; UP-REGULATION;
D O I
10.3390/ijms25115810
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Inflammatory skin diseases highlight inflammation as a central driver of skin pathologies, involving a multiplicity of mediators and cell types, including immune and non-immune cells. Adenosine, a ubiquitous endogenous immune modulator, generated from adenosine triphosphate (ATP), acts via four G protein-coupled receptors (A1, A2A, A2B, and A3). Given the widespread expression of those receptors and their regulatory effects on multiple immune signaling pathways, targeting adenosine receptors emerges as a compelling strategy for anti-inflammatory intervention. Animal models of psoriasis, contact hypersensitivity (CHS), and other dermatitis have elucidated the involvement of adenosine receptors in the pathogenesis of these conditions. Targeting adenosine receptors is effective in attenuating inflammation and remodeling the epidermal structure, potentially showing synergistic effects with fewer adverse effects when combined with conventional therapies. What is noteworthy are the promising outcomes observed with A2A agonists in animal models and ongoing clinical trials investigating A3 agonists, underscoring a potential therapeutic approach for the management of inflammatory skin disorders.
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页数:22
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共 129 条
[1]   Susceptibility of aging mice to listeriosis: Role of anti-inflammatory responses with enhanced Treg-cell expression of CD39/CD73 and Th-17 cells [J].
Alam, M. Samiul ;
Cavanaugh, Christopher ;
Pereira, Marion ;
Babu, Uma ;
Williams, Kristina .
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY, 2020, 310 (02)
[2]   Adenosine A2A and A2B Receptors Differentially Modulate Keratinocyte Proliferation: Possible Deregulation in Psoriatic Epidermis [J].
Andres, Rosa M. ;
Carmen Terencio, Maria ;
Arasa, Jorge ;
Paya, Miguel ;
Valcuende-Cavero, Francisca ;
Navalon, Pedro ;
Carmen Montesinos, Maria .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2017, 137 (01) :123-131
[3]   ADENOSINE AND INSULIN MEDIATE GLUCOSE-UPTAKE IN NORMOXIC RAT HEARTS BY DIFFERENT MECHANISMS [J].
ANGELLO, DA ;
BERNE, RM ;
CODDINGTON, NM .
AMERICAN JOURNAL OF PHYSIOLOGY, 1993, 265 (03) :H880-H885
[4]  
[Anonymous], Translational Therapeutics of Dipyridamole|Arteriosclerosis, Thrombosis, and Vascular Biology, DOI [10.1161/atvbaha.107.160226, DOI 10.1161/ATVBAHA.107.160226]
[5]   Adenosine signaling and the immune system: When a lot could be too much [J].
Antonioli, Luca ;
Fornai, Matteo ;
Blandizzi, Corrado ;
Pacher, Pal ;
Hasko, Gyorgy .
IMMUNOLOGY LETTERS, 2019, 205 :9-15
[6]   Topical application of the adenosine A2A receptor agonist CGS-21680 prevents phorbol-induced epidermal hyperplasia and inflammation in mice [J].
Arasa, Jorge ;
Martos, Patricio ;
Carmen Terencio, Maria ;
Valcuende-Cavero, Francisca ;
Carmen Montesinos, Maria .
EXPERIMENTAL DERMATOLOGY, 2014, 23 (08) :555-560
[7]   Extracellular Adenosine Mediates a Systemic Metabolic Switch during Immune Response [J].
Bajgar, Adam ;
Kucerova, Katerina ;
Jonatova, Lucie ;
Tomcala, Ales ;
Schneedorferova, Ivana ;
Okrouhlik, Jan ;
Dolezal, Tomas .
PLOS BIOLOGY, 2015, 13 (04)
[8]   Long-term Safety of Oral Systemic Therapies for Psoriasis: A Comprehensive Review of the Literature [J].
Balak, Deepak M. W. ;
Gerdes, Sascha ;
Parodi, Aurora ;
Salgado-Boquete, Laura .
DERMATOLOGY AND THERAPY, 2020, 10 (04) :589-613
[9]   The equilibrative nucleoside transporter family, SLC29 [J].
Baldwin, SA ;
Beal, PR ;
Yao, SYM ;
King, AE ;
Cass, CE ;
Young, JD .
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2004, 447 (05) :735-743
[10]   Cyclic adenosine monophosphate (cAMP) signaling in melanocyte pigmentation and melanomagenesis [J].
Bang, Jakyung ;
Zippin, Jonathan H. .
PIGMENT CELL & MELANOMA RESEARCH, 2021, 34 (01) :28-43