MicroRNA-322-5p protects against myocardial infarction through targeting BTG2

Background: Numerous studies have explored the therapeutic potential of microRNA (miR) in myocardial infarction (MI) treatment. This study focuses on the role of miR-322-5p in MI, particularly in its regulatory interaction with B -cell translocation gene 2 (BTG2). Materials and methods: Expression levels of miR-322-5p and BTG2 were assessed in a rat MI model. Adenovirus altering miR-322-5p or BTG2 expression were administered to MI rats. Evaluation included cardiac function, in flammation, myocardial injury, pathological changes, apoptosis, and NF - K B pathway -related genes in MI rats post -targeted treatment. The miR-3225p and BTG2 targeting relationship was investigated. Results: MI rats exhibited low miR-322-5p and high BTG2 expression in the myocardial tissues. Restoration of miR-322-5p enhanced cardiac function, alleviated in flammation and myocardial injury, mitigated pathological changes and apoptosis, and deactivated the NF - K B pathway in MI rats. BTG2 expression was negatively -regulated by miR-322-5p. Overexpressed BTG2 counteracted miR-322-5p-induced cardioprotection on MI rats. Conclusion: This study provides evidence that miR-322-5p protects against MI by suppressing BTG2 expression.