Osteoarthritis in People with Multiple Sclerosis: A Systematic Review and Meta-Analysis

被引:0
作者
Giannopapas, Vasileios [1 ,2 ]
Smyrni, Vassiliki [1 ]
Kitsos, Dimitrios K. [1 ]
Stasi, Sophia [3 ]
Chasiotis, Athanasios K. [1 ,2 ]
Moschovos, Christos [1 ]
Papagiannopoulou, Georgia [1 ]
Stavrogianni, Konstantina [1 ,4 ]
Kosmidou, Maria [5 ]
Bakalidou, Daphne [1 ]
Tzartos, John S. [1 ]
Tsivgoulis, Georgios [1 ]
Giannopoulos, Sotirios [1 ]
机构
[1] Natl & Kapodistrian Univ Athens, Dept Neurol 2, Athens 11528, Greece
[2] Univ West Attica, Dept Phys Therapy, Egaleo 12243, Greece
[3] Univ Peloponnese, Dept Phys Therapy, Sparti 23100, Greece
[4] Univ Ioannina, Fac Med, Dept Physiol, 45110 Ioannina, Greece
[5] Univ Ioannina, Fac Med, Dept Internal Med, Ioannina 45110, Greece
关键词
multiple sclerosis; arthritis; osteoarthritis; autoimmune diseases; NATIONAL BURDEN; GLOBAL BURDEN; DISEASE; EPIDEMIOLOGY; STROKE;
D O I
10.3390/jcm13175015
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Arthritis, particularly osteoarthritis (OA), is a common synovial condition observed in individuals with multiple sclerosis (MS). Despite its high prevalence and significant impact on the quality of life of MS individuals, there is a gap in the current literature regarding the prevalence of OA in this population and its relation to MS pathology. This systematic review and meta-analysis aimed to estimate the prevalence of OA in the MS population and explore potential associations with demographic and MS-specific characteristics. Methods: Adhering to PRISMA guidelines, a systematic search of the MEDLINE PubMed, Scopus and Google Scholar databases was conducted. Results: Fifteen studies were included in the systematic review and meta-analysis. The aggregated prevalence of OA in the MS population was 27% (95% CI: 15-40%), with substantial heterogeneity (I2 = 99.9%). Sensitivity analysis, excluding one study, showed a prevalence of 21% (95% CI: 16-28%). The risk ratio of OA in MS versus controls was 1.07 (95% CI: 0.84-1.37), indicating no significant difference. Meta-regression revealed no associations between OA prevalence and age or disease duration in MS patients. Conclusions: This study reports a 21-27% prevalence of OA in people with MS. Understanding the implications of OA in pain and mobility domains, as well as the challenges in distinguishing OA symptoms from MS manifestations, underscores the need for further research to elucidate the pathophysiological mechanisms and interactions between these conditions. Additional studies are warranted to enhance clinical management and improve outcomes for individuals with MS and co-existing OA.
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页数:13
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共 54 条
[31]   The Epidemiology, Etiology, Diagnosis, and Treatment of Osteoarthritis of the Knee [J].
Michael, Joern W-P. ;
Schlueter-Brust, Klaus U. ;
Eysel, Peer .
DEUTSCHES ARZTEBLATT INTERNATIONAL, 2010, 107 (09) :152-U39
[32]   Steroid-induced osteonecrosis [J].
Motta, Francesca ;
Timilsina, Suraj ;
Gershwin, M. Eric ;
Selmi, Carlo .
JOURNAL OF TRANSLATIONAL AUTOIMMUNITY, 2022, 5
[33]  
Na Meng-Qi, 2017, Zhongguo Gu Shang, V30, P345, DOI 10.3969/j.issn.1003-0034.2017.04.012
[34]   Obesity, Inflammation, and Immune System in Osteoarthritis [J].
Nedunchezhiyan, Udhaya ;
Varughese, Ibin ;
Sun, Antonia RuJia ;
Wu, Xiaoxin ;
Crawford, Ross ;
Prasadam, Indira .
FRONTIERS IN IMMUNOLOGY, 2022, 13
[35]   The Presence of Symptoms With Comorbid Conditions in Individuals With Multiple Sclerosis (MS) [J].
Newland, Pamela K. ;
Lorenz, Rebecca ;
Budhathoki, Chakra ;
Jensen, Mark P. .
CLINICAL NURSING RESEARCH, 2016, 25 (05) :532-548
[36]  
Page MJ, 2021, BMJ-BRIT MED J, V372, DOI [10.1136/bmj.n71, 10.1136/bmj.n160, 10.1016/j.ijsu.2021.105906]
[37]   Effect of Chronic Medical Conditions in Veterans with Multiple Sclerosis on Long-Term Disability [J].
Rabadi, Meheroz H. ;
Aston, Christopher E. .
MEDICAL SCIENCE MONITOR, 2016, 22 :2768-2774
[38]   Impaired glucose transporter-1 degradation and increased glucose transport and oxidative stress in response to high glucose in chondrocytes from osteoarthritic versus normal human cartilage [J].
Rosa, Susana C. ;
Goncalves, Juliana ;
Judas, Fernando ;
Mobasheri, Ali ;
Lopes, Celeste ;
Mendes, Alexandrina F. .
ARTHRITIS RESEARCH & THERAPY, 2009, 11 (03)
[39]   Global, regional and national burden of osteoarthritis 1990-2017: a systematic analysis of the Global Burden of Disease Study 2017 [J].
Safiri, Saeid ;
Kolahi, Ali-Asghar ;
Smith, Emma ;
Hill, Catherine ;
Bettampadi, Deepti ;
Mansournia, Mohammad Ali ;
Hoy, Damian ;
Ashrafi-Asgarabad, Ahad ;
Sepidarkish, Mahdi ;
Almasi-Hashiani, Amir ;
Collins, Gary ;
Kaufman, Jay ;
Qorbani, Mostafa ;
Moradi-Lakeh, Maziar ;
Woolf, Anthony D. ;
Guillemin, Francis ;
March, Lyn ;
Cross, Marita .
ANNALS OF THE RHEUMATIC DISEASES, 2020, 79 (06) :819-828
[40]   Involvement of CD8+ T Cells in Multiple Sclerosis [J].
Salou, Marion ;
Nicol, Bryan ;
Garcia, Alexandra ;
Laplaud, David-Axel .
FRONTIERS IN IMMUNOLOGY, 2015, 6